Comprehensive metabolic panel

Comprehensive metabolic panel
Comprehensive metabolic panel

Computer screen report of a Comprehensive metabolic panel.
LOINC 24322-0, 24323-8

The comprehensive metabolic panel, or chemical screen, (CMP; CPT code 80053) is a panel of 14 blood tests which serves as an initial broad screening tool for physicians, nurse practitioners and physician assistants. Because it is often ordered as a routine part of an annual physical examination or check up, over time the CMP provides an important baseline of a patient's basic physiology. Any changes or abnormal results, and in particular combinations of abnormal results, thus provides important initial data for differential diagnosis, in which case more specialized tests may be indicated. In and of itself, however, the CMP provides an important gross check on the status of kidney function, liver function, and electrolyte and fluid balance.

In addition to being used at routine physicals of healthy patients, the CMP is routinely administered to monitor the status of a patient with a chronic disease, such as diabetes mellitus or hypertension.

Previous names for the panel of tests have been Chem 12, Chemistry panel, Chemistry screen, SMA 12, SMA 20 and SMAC (Sequential Multiple Analysis - Computer).[1] The tests are performed on machines based on the AutoAnalyzer invented in 1957.



Pathophysiology sample values
Na+=140 Cl=100 BUN=20 /
K+=4 CO2=22 PCr=1.0 \
HCO3-=24 paCO2=40 paO2=95 pH=7.40
pACO2=36 pAO2=105 A-a g=10
Ca=9.5 Mg2+=2.0 PO4=1
CK=55 BE=−0.36 AG=16
PMO = 300 PCO=295 POG=5 BUN:Cr=20
UNa+=80 UCl=100 UAG=5 FENa=0.95
UK+=25 USG=1.01 UCr=60 UO=800
LDH=100 TP=7.6 AST=25 TBIL=0.7
ALP=71 Alb=4.0 ALT=40 BC=0.5
AST/ALT=0.6 BU=0.2
AF alb=3.0 SAAG=1.0 SOG=60
CSF alb=30 CSF glu=60 CSF/S alb=7.5 CSF/S glu=0.4

Typically, the patient fasts for ten or twelve hours before the blood is drawn for the test. The following tests are then performed:[1]

General tests

These tests help screen for a wide variety of problems. The glucose test in particular helps screen for diabetes mellitus and pre-diabetes. The calcium test can indicate or monitor bone diseases or diseases of the parathyroid gland or kidneys. Calcium salts, Lithium, Thiazide diuretics, Thyroxine, and vitamin D can all increase levels and may interfere with this test.[2]

Protein tests

Tests of protein levels in the blood help screen for both kidney and liver disorders.


Electrolyte levels and the balance among them are tightly regulated by the body. Both individual values and ratios among the values are significant; abnormalities among either can indicate problems such as an electrolyte disturbance, acid-base imbalance, or kidney dysfunction.

Kidney function assessment

Liver function assessment


  1. ^ a b "Comprehensive Metabolic Panel". Lab Tests Online. 2005-10-31. Retrieved 2008-09-22. 
  2. ^

See also

External links

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