- Mepolizumab
-
Mepolizumab ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target IL-5 Clinical data Pregnancy cat. ? Legal status ? Pharmacokinetic data Half-life 19 days Identifiers CAS number 196078-29-2 
ATC code L04AC06 KEGG D04923 Chemical data Formula ? 
(what is this?) (verify)Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases.
Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma.
IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.[1] Mepolizumab improved the quality of life, but the improvement was "not clinically meaningful," according to a reviewer.[2] [3]
Mepolizumab is also in development for the management of hypereosinophilic syndrome by GlaxoSmithKline (GSK) and has received orphan drug designation by the FDA.[4] Mepolizumab has been shown to reduce the need for corticosteroids and improve symptoms in FIP1L1/PDGFRA negative hypereosinophilic syndrome.[5]
References
- ^ Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009 Mar 5;360(10):973-84.
- ^ Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009 Mar 5;360(10):985-93.
- ^ Eosinophils in asthma – closing the loop or opening the door? Sally E. Wenzel, N Engl J Med. 2009 Mar 5;360(10):1026-7.
- ^ Phase III study of Bosatria (mepolizumab) showed disease control with reduced corticosteroid use in hypereosinophilic syndrome
- ^ http://content.nejm.org/cgi/content/abstract/358/12/1215 Rothenberg et al 2008
Monoclonal antibodies for the immune system Immune system ("-l(i[m])-") Human ("-limu-")immunosuppression: Adalimumab • Atorolimumab • Brodalumab • Carlumab • Fresolimumab • Golimumab • Lerdelimumab • Mavrilimumab • Metelimumab • Morolimumab • Namilumab • Oxelumab • Sarilumab • Sifalimumab • Tabalumab • Urelumab
immune activation: Ipilimumab • Tremelimumab
other: Bertilimumab • ZanolimumabMouse ("-limo-")Chimeric ("-lixi-")Basiliximab • Clenoliximab • Galiximab • Gomiliximab • Infliximab • Keliximab • Lumiliximab • Priliximab • Teneliximab • VapaliximabHumanized ("-lizu-")immunosuppressive: Aselizumab • Apolizumab • Benralizumab† • Cedelizumab • Certolizumab pegol • Daclizumab • Eculizumab • Efalizumab • Epratuzumab • Erlizumab • Etrolizumab • Fontolizumab • Itolizumab • Mepolizumab • Mogamulizumab • Natalizumab • Ocrelizumab • Omalizumab • Ozoralizumab • Pascolizumab • Pateclizumab • Pexelizumab • PRO 140† • Reslizumab • Rontalizumab • Rovelizumab • Ruplizumab • Samalizumab • Siplizumab • Talizumab • Teplizumab • Tocilizumab • Toralizumab • Tregalizumab • Vatelizumab • Vedolizumab • Visilizumab • TGN1412§
non-immunosuppressive: Ibalizumab†Chimeric + humanized
("-lixizu-")Interleukin ("-k(i[n])-") Human ("-kinu-")Briakinumab • Canakinumab • Fezakinumab • Secukinumab • Sirukumab • Tralokinumab • UstekinumabHumanized ("-kizu-", "-kinzu-")Anrukinzumab • Enokizumab • Gevokizumab • Ixekizumab • Lebrikizumab • OlokizumabInflammatory lesions ("-les-") Mouse ("-leso-")#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III 
This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it. This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.
