Humanized antibody

Humanized antibody

Humanized antibodies or chimeric antibodies are a type of monoclonal antibody that have been synthesized using recombinant DNA technology to circumvent the clinical problem of immune response to foreign antigens. The standard procedure of producing monoclonal antibodies yields mouse antibodies. Although murine antibodies are very similar to human ones there are differences, and the human immune system recognizes mouse antibodies as foreign, rapidly removing them from circulation and causing systemic inflammatory effects.

Humanized antibodies are produced by merging the DNA that encodes the binding portion of a monoclonal mouse antibody with human antibody-producing DNA. One then uses mammalian cell cultures to express this DNA and produce these half-mouse and half-human antibodies that are not as immunogenic as the murine variety.


A solution to this problem would be to generate human antibodies directly from humans. However, this is not easy, primarily because it is not clearly ethical to challenge humans with antigen in order to produce antibody. Furthermore, it is not easy to generate human antibodies against human tissues.

ee also

* Examples in monoclonal antibody, for clinical examples

template group
title = Humanized and chimeric antibodies
list =

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • humanized antibody — Usually a mouse monoclonal antibody directed against a target of particular therapeutic value that has been modified to have all regions except the antigen binding portion substituted by human immunoglobulin domains. The procedure should make the …   Dictionary of molecular biology

  • humanized monoclonal antibody — A type of antibody made in the laboratory by combining a human antibody with a small part of a mouse or rat monoclonal antibody. The mouse or rat part of the antibody binds to the target antigen, and the human part makes it less likely to be… …   English dictionary of cancer terms

  • humanized — verb a monoclonal antibody derived from a mostly human source …   Wiktionary

  • Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… …   Wikipedia

  • maytansinoid DM4-conjugated humanized monoclonal antibody huC242 — A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody locates and binds to the surfaces of cancer cells and… …   English dictionary of cancer terms

  • Nomenclature of monoclonal antibodies — List of stems for monoclonal antibody nomenclature[1][2][3] …   Wikipedia

  • Omalizumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target IgE Fc region …   Wikipedia

  • Cancer immunotherapy — is the use of the immune system to reject cancer. The main premise is stimulating the patient s immune system to attack the malignant tumor cells that are responsible for the disease. This can be either through immunization of the patient, in… …   Wikipedia

  • IGKC — Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes a the constant domain of kappa type light chains for antibodies.cite web | title = Entrez Gene: IGKC immunoglobulin kappa constant| url =… …   Wikipedia

  • IGHG1 — Immunoglobulin heavy constant gamma 1 (G1m marker), also known as IGHG1, is a human gene.cite web | title = Entrez Gene: IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)| url =… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”