IGKC

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes a the constant domain of kappa-type light chains for antibodies.cite web | title = Entrez Gene: IGKC immunoglobulin kappa constant| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3514| accessdate = ] It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@. PBB_Summary
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References

Further reading

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*cite journal | author=Brady RL, Edwards DJ, Hubbard RE, "et al." |title=Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells. |journal=J. Mol. Biol. |volume=227 |issue= 1 |pages= 253–64 |year= 1992 |pmid= 1522589 |doi=
*cite journal | author=Titani K, Shinoda T, Putnam FW |title=The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges. |journal=J. Biol. Chem. |volume=244 |issue= 13 |pages= 3550–60 |year= 1969 |pmid= 4893682 |doi=
*cite journal | author=Gall WE, Edelman GM |title=The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. |journal=Biochemistry |volume=9 |issue= 16 |pages= 3188–96 |year= 1971 |pmid= 4923144 |doi=
*cite journal | author=Suter L, Barnikol HU, Watanabe S, Hilschmann N |title= [Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=353 |issue= 2 |pages= 189–208 |year= 1972 |pmid= 5027703 |doi=
*cite journal | author=Kohler H, Shimizu A, Paul C, Putnam FW |title=Macroglobulin structure: variable sequence of light and heavy chains. |journal=Science |volume=169 |issue= 940 |pages= 56–9 |year= 1970 |pmid= 5447531 |doi=
*cite journal | author=Gottlieb PD, Cunningham BA, Rutishauser U, Edelman GM |title=The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain. |journal=Biochemistry |volume=9 |issue= 16 |pages= 3155–61 |year= 1971 |pmid= 5489770 |doi=
*cite journal | author=Hilschmann N |title= [The complete amino acid sequence of Bence Jones protein Cum (kappa-type)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=348 |issue= 12 |pages= 1718–22 |year= 1968 |pmid= 5586923 |doi=
*cite journal | author=Klobeck HG, Combriato G, Zachau HG |title=Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related. |journal=Nucleic Acids Res. |volume=12 |issue= 18 |pages= 6995–7006 |year= 1984 |pmid= 6091049 |doi=
*cite journal | author=Hieter PA, Maizel JV, Leder P |title=Evolution of human immunoglobulin kappa J region genes. |journal=J. Biol. Chem. |volume=257 |issue= 3 |pages= 1516–22 |year= 1982 |pmid= 6276389 |doi=
*cite journal | author=Emorine L, Kuehl M, Weir L, "et al." |title=A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element. |journal=Nature |volume=304 |issue= 5925 |pages= 447–9 |year= 1983 |pmid= 6308460 |doi=
*cite journal | author=Bentley DL, Rabbitts TH |title=Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion. |journal=Cell |volume=32 |issue= 1 |pages= 181–9 |year= 1983 |pmid= 6402305 |doi=
*cite journal | author=Hieter PA, Max EE, Seidman JG, "et al." |title=Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. |journal=Cell |volume=22 |issue= 1 Pt 1 |pages= 197–207 |year= 1981 |pmid= 6775818 |doi=
*cite journal | author=Bentley DL, Rabbits TH |title=Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene. |journal=Nature |volume=288 |issue= 5792 |pages= 730–3 |year= 1981 |pmid= 6779204 |doi=
*cite journal | author=Huber C, Schäble KF, Huber E, "et al." |title=The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line. |journal=Eur. J. Immunol. |volume=23 |issue= 11 |pages= 2868–75 |year= 1993 |pmid= 8223863 |doi=
*cite journal | author=Olsen KE, Sletten K, Westermark P |title=Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 713–6 |year= 1998 |pmid= 9588180 |doi= 10.1006/bbrc.1998.8515
*cite journal | author=Wally J, Kica G, Zhang Y, "et al." |title=Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. |journal=Biochim. Biophys. Acta |volume=1454 |issue= 1 |pages= 49–56 |year= 1999 |pmid= 10354514 |doi=
*cite journal | author=Hotta K, Lange H, Tantillo DJ, "et al." |title=Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. |journal=J. Mol. Biol. |volume=302 |issue= 5 |pages= 1213–25 |year= 2000 |pmid= 11183784 |doi= 10.1006/jmbi.2000.4503
*cite journal | author=Karpusas M, Lucci J, Ferrant J, "et al." |title=Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody. |journal=Structure |volume=9 |issue= 4 |pages= 321–9 |year= 2001 |pmid= 11525169 |doi=
*cite journal | author=Davis DP, Gallo G, Vogen SM, "et al." |title=Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain. |journal=J. Mol. Biol. |volume=313 |issue= 5 |pages= 1021–34 |year= 2001 |pmid= 11700059 |doi= 10.1006/jmbi.2001.5092
*cite journal | author=Pandey JP, Frederick M, |title=TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. |journal=Hum. Immunol. |volume=63 |issue= 6 |pages= 485–91 |year= 2002 |pmid= 12039524 |doi=

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