ICA1

Islet cell autoantigen 1, 69kDa, also known as ICA1, is a human gene.cite web | title = Entrez Gene: ICA1 islet cell autoantigen 1, 69kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3382| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: ICA1 islet cell autoantigen 1, 69kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3382| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nepom GT |title=Glutamic acid decarboxylase and other autoantigens in IDDM. |journal=Curr. Opin. Immunol. |volume=7 |issue= 6 |pages= 825–30 |year= 1996 |pmid= 8679127 |doi=
*cite journal | author=Thai AC, Ng WY, Lui KF, Cheah JS |title=Islet cell and thyroid autoimmunity in Chinese patients with IDDM. |journal=Diabetes Care |volume=18 |issue= 4 |pages= 586–7 |year= 1996 |pmid= 7497880 |doi=
*cite journal | author=Martin S, Kardorf J, Schulte B, "et al." |title=Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. |journal=Diabetologia |volume=38 |issue= 3 |pages= 351–5 |year= 1995 |pmid= 7758883 |doi=
*cite journal | author=Miyazaki I, Cheung RK, Gaedigk R, "et al." |title=T cell activation and anergy to islet cell antigen in type I diabetes. |journal=J. Immunol. |volume=154 |issue= 3 |pages= 1461–9 |year= 1995 |pmid= 7822811 |doi=
*cite journal | author=Lampasona V, Ferrari M, Bosi E, "et al." |title=Sera from patients with IDDM and healthy individuals have antibodies to ICA69 on western blots but do not immunoprecipitate liquid phase antigen. |journal=J. Autoimmun. |volume=7 |issue= 5 |pages= 665–74 |year= 1995 |pmid= 7840858 |doi= 10.1006/jaut.1994.1051
*cite journal | author=Miyazaki I, Gaedigk R, Hui MF, "et al." |title=Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes. |journal=Biochim. Biophys. Acta |volume=1227 |issue= 1-2 |pages= 101–4 |year= 1994 |pmid= 7918678 |doi=
*cite journal | author=Gaedigk R, Duncan AM, Miyazaki I, "et al." |title=ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 4 |pages= 274–6 |year= 1994 |pmid= 8162706 |doi=
*cite journal | author=Pietropaolo M, Castaño L, Babu S, "et al." |title=Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. |journal=J. Clin. Invest. |volume=92 |issue= 1 |pages= 359–71 |year= 1993 |pmid= 8326004 |doi=
*cite journal | author=Karges W, Pietropaolo M, Ackerley CA, Dosch HM |title=Gene expression of islet cell antigen p69 in human, mouse, and rat. |journal=Diabetes |volume=45 |issue= 4 |pages= 513–21 |year= 1996 |pmid= 8603775 |doi=
*cite journal | author=Mally MI, Cirulli V, Hayek A, Otonkoski T |title=ICA69 is expressed equally in the human endocrine and exocrine pancreas. |journal=Diabetologia |volume=39 |issue= 4 |pages= 474–80 |year= 1996 |pmid= 8777998 |doi=
*cite journal | author=Martin S, Lampasona V, Dosch M, Pietropaolo M |title=Islet cell autoantigen 69 antibodies in IDDM. |journal=Diabetologia |volume=39 |issue= 6 |pages= 747 |year= 1996 |pmid= 8781774 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Gaedigk R, Karges W, Hui MF, "et al." |title=Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity. |journal=Genomics |volume=38 |issue= 3 |pages= 382–91 |year= 1997 |pmid= 8975715 |doi= 10.1006/geno.1996.0641
*cite journal | author=Stassi G, Schloot N, Pietropaolo M |title=Islet cell autoantigen 69 kDa (ICA69) is preferentially expressed in the human islets of Langerhans than exocrine pancreas. |journal=Diabetologia |volume=40 |issue= 1 |pages= 120–2 |year= 1997 |pmid= 9028728 |doi=
*cite journal | author=Rønningen KS, Atrazhev A, Luo L, "et al." |title=Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69. |journal=J. Autoimmun. |volume=11 |issue= 3 |pages= 223–31 |year= 1998 |pmid= 9693970 |doi= 10.1006/jaut.1998.0199
*cite journal | author=Kerokoski P, Ilonen J, Gaedigk R, "et al." |title=Production of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritis. |journal=Autoimmunity |volume=29 |issue= 4 |pages= 281–9 |year= 1999 |pmid= 10433084 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Winer S, Astsaturov I, Cheung R, "et al." |title=Primary Sjögren's syndrome and deficiency of ICA69. |journal=Lancet |volume=360 |issue= 9339 |pages= 1063–9 |year= 2002 |pmid= 12383988 |doi=
*cite journal | author=Friday RP, Pietropaolo SL, Profozich J, "et al." |title=Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 853–63 |year= 2003 |pmid= 12409289 |doi= 10.1074/jbc.M210175200

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