- HRB (gene)
HIV-1 Rev binding protein, also known as HRB, is a human
gene .cite web | title = Entrez Gene: HRB HIV-1 Rev binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3267| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.cite web | title = Entrez Gene: HRB HIV-1 Rev binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3267| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Li L, Li HS, Pauza CD, "et al." |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370
*cite journal | author=Bogerd HP, Fridell RA, Madore S, Cullen BR |title=Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. |journal=Cell |volume=82 |issue= 3 |pages= 485–94 |year= 1995 |pmid= 7634337 |doi=
*cite journal | author=Fritz CC, Zapp ML, Green MR |title=A human nucleoporin-like protein that specifically interacts with HIV Rev. |journal=Nature |volume=376 |issue= 6540 |pages= 530–3 |year= 1995 |pmid= 7637788 |doi= 10.1038/376530a0
*cite journal | author=Fridell RA, Bogerd HP, Cullen BR |title=Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 9 |pages= 4421–4 |year= 1996 |pmid= 8633082 |doi=
*cite journal | author=Fritz CC, Green MR |title=HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 848–54 |year= 1997 |pmid= 8805303 |doi=
*cite journal | author=Stutz F, Izaurralde E, Mattaj IW, Rosbash M |title=A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7144–50 |year= 1997 |pmid= 8943370 |doi=
*cite journal | author=Jones T, Sheer D, Bevec D, "et al." |title=The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36. |journal=Genomics |volume=40 |issue= 1 |pages= 198–9 |year= 1997 |pmid= 9070945 |doi= 10.1006/geno.1996.4457
*cite journal | author=Salcini AE, Confalonieri S, Doria M, "et al." |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=
*cite journal | author=Neville M, Stutz F, Lee L, "et al." |title=The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. |journal=Curr. Biol. |volume=7 |issue= 10 |pages= 767–75 |year= 1998 |pmid= 9368759 |doi=
*cite journal | author=Güre AO, Altorki NK, Stockert E, "et al." |title=Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. |journal=Cancer Res. |volume=58 |issue= 5 |pages= 1034–41 |year= 1998 |pmid= 9500467 |doi=
*cite journal | author=Farjot G, Sergeant A, Mikaélian I |title=A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17309–17 |year= 1999 |pmid= 10358091 |doi=
*cite journal | author=Doria M, Salcini AE, Colombo E, "et al." |title=The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. |journal=J. Cell Biol. |volume=147 |issue= 7 |pages= 1379–84 |year= 2000 |pmid= 10613896 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Yang J, Bogerd HP, Wang PJ, "et al." |title=Two closely related human nuclear export factors utilize entirely distinct export pathways. |journal=Mol. Cell |volume=8 |issue= 2 |pages= 397–406 |year= 2001 |pmid= 11545741 |doi=
*cite journal | author=Chen D, Li X, Zhai Z, Shu HB |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15985–91 |year= 2002 |pmid= 11854271 |doi= 10.1074/jbc.M108675200
*cite journal | author=Scherl A, Couté Y, Déon C, "et al." |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kiss A, Li L, Gettemeier T, Venkatesh LK |title=Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors. |journal=Virology |volume=314 |issue= 2 |pages= 591–600 |year= 2003 |pmid= 14554087 |doi=
*cite journal | author=Sánchez-Velar N, Udofia EB, Yu Z, Zapp ML |title=hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. |journal=Genes Dev. |volume=18 |issue= 1 |pages= 23–34 |year= 2004 |pmid= 14701878 |doi= 10.1101/gad.1149704
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285PBB_Controls
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