Teplizumab

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type = mab


source = Human
target = CD3
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Teplizumab is a monoclonal antibody which it is used as an immunosuppressive drug. It is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala) [Woodle, E.S., Bluestone, J., Zivin, R., Jolliffe, L., Auger, J., Xu, D., and J. Thistlethwaite. "Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience." (1998) [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9636555 Transplant Proc. 30:1369-1370] ] [Brown, W.M. "Anti-CD3 antibody MacroGenics Inc." (2006) [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16625825 Curr Opin Investig Drugs, 74:381-8.] ] .

References

External links

* [http://www.macrogenics.com/pipeline/autoimmunity.mspx] MacroGenics, Inc.