- Climbazole
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Climbazole Systematic (IUPAC) name (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one [1] Clinical data Pregnancy cat. ? Legal status ? Routes topical Identifiers CAS number 38083-17-9 ATC code None UNII 9N42CW7I54 Chemical data Formula C15H17ClN2 Mol. mass 292.76 (what is this?) (verify) Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.
Indications and formulations
It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Side effects
May cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]
References
- ^ Chemical Properties of Climbazole
- ^ a b Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis 90 (33): 1346–9. PMID 11534318.
Antifungals (D01 and J02) Wall/
membranetopical: Bifonazole, Clomidazole, Clotrimazole#, Croconazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole#, Neticonazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazoletopical: (Fluconazole#, Fosfluconazole)
systemic: (Fluconazole, Hexaconazole, Itraconazole, Posaconazole, Voriconazole)topical: ThiabendazoleIntracellular Others Bromochlorosalicylanilide • Methylrosaniline • Tribromometacresol • Undecylenic acid • Polynoxylin • Chlorophetanol • Chlorphenesin • Ticlatone • Sulbentine • Ethyl hydroxybenzoate • Haloprogin • Salicylic acid • Selenium sulfide# • Ciclopirox • Amorolfine • Dimazole • Tolnaftate • Tolciclate • Sodium thiosulfate# • Whitfield's ointment# • Potassium iodide#
Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle
PCP: Pentamidine • Dapsone • Atovaquone#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III Categories:- Antifungals
- Imidazoles
- Phenol ethers
- Organochlorides
- Ketones
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