Climbazole

Climbazole

Systematic (IUPAC) name
(RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one [1]
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	topical
Identifiers
CAS number	38083-17-9
ATC code	None
UNII	9N42CW7I54 Y
Chemical data
Formula	C15H17ClN2
Mol. mass	292.76
Y(what is this?)  (verify)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff^[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.^[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.^{[citation needed]}

References

1. ^ Chemical Properties of Climbazole
2. ^ ^{a b} Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis 90 (33): 1346–9. PMID 11534318.