- Polyene antimycotic
Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of
antimicrobial polyenecompounds that target fungi. Amphotericin B, nystatin, and natamycinare examples of polyene antimycotics. Their chemical structures feature a large ring of atoms (essentially a cyclic esterring) containing multiple conjugated carbon-carbon double bonds (hence " polyene") on one side of the ring and multiple hydroxylgroups bonded to the other side of the ring. Their structures also often have a "d"-mycosamine (a type of amino-glycoside) group bonded to the molecule. [ [http://content.febsjournal.org/cgi/content/full/269/18/4533 Solution NMR structure of five representative glycosylated polyene macrolide antibiotics] ] The series of conjugated double bonds typically absorbs strongly in the ultraviolet-visible region of the electromagnetic spectrum, often resulting in the polyene antibiotics having a yellow color.
These polyene antimycotics are typically obtained from some species of "
Streptomyces" bacteria. The polyenes bind to ergosterolin the fungal cell membrane and promote leakiness which may contribute to fungal cell death.
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