Amorolfine

Amorolfine

drugbox
IUPAC_name = (2"S",6"R")-2,6-dimethyl-4- [2-methyl-3- [4-
(2-methylbutan-2-yl)phenyl] propyl] morpholine


CAS_number = 78613-35-1
ATC_prefix = D01
ATC_suffix = AE16
PubChem = 54260
DrugBank =
C=21|H=35|N=1|O=
molecular_weight = 317.509 g/mol
bioavailability =
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metabolism =
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pregnancy_AU =
pregnancy_US =
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Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.


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