Croconazole

Croconazole

Systematic (IUPAC) name
1-(1-{2-[(3-chlorophenyl)methoxy]phenyl}ethenyl)-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Topical
Identifiers
CAS number	77175-51-0
ATC code	None
PubChem	CID 2880
ChemSpider	2777
UNII	446254H55G Y
KEGG	D07752
ChEMBL	CHEMBL27289
Chemical data
Formula	C18H15ClN2O
Mol. mass	310.77 g/mol
SMILES	eMolecules & PubChem

Croconazole (INN) is an imidazole antifungal.

Polyene antimycotics
(ergosterol binding)

topical: (Natamycin, Nystatin^#)
systemic: (Amphotericin B^#)

Allylamines
(squalene monooxygenase
inhibitors)

topical: (Amorolfine, Butenafine, Naftifine, Terbinafine)
systemic: (Terbinafine)

β-glucan synthase
inhibitors

echinocandins (Anidulafungin, Caspofungin, Micafungin)

Intracellular

Pyrimidine analogues/ Thymidylate synthase inhibitors	Flucytosine#
Mitotic inhibitors	Griseofulvin#

Others

Bromochlorosalicylanilide • Methylrosaniline • Tribromometacresol • Undecylenic acid • Polynoxylin • Chlorophetanol • Chlorphenesin • Ticlatone • Sulbentine • Ethyl hydroxybenzoate • Haloprogin • Salicylic acid • Selenium sulfide^# • Ciclopirox • Amorolfine • Dimazole • Tolnaftate • Tolciclate • Sodium thiosulfate^# • Whitfield's ointment^# • Potassium iodide^#

Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle

PCP: Pentamidine • Dapsone • Atovaquone

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYC fung, clas fung drug (fung)