Dimemorfan

Dimemorfan
Dimemorfan
Systematic (IUPAC) name
(9α,13α,14α)-3,17-dimethylmorphinan
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 36309-01-0
ATC code R05DA11
PubChem CID 3037918
ChemSpider 16735785 YesY
UNII 623OAC38YU YesY
KEGG D07848 YesY
Chemical data
Formula C18H25N 
Mol. mass 255.398 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.[1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.[3]

See also

References

  1. ^ Wang, H. H.; Chien, J. W.; Chou, Y. C.; Liao, J. F.; Chen, C. F. (2003). "Anti-amnesic effect of dimemorfan in mice". British Journal of Pharmacology 138 (5): 941–949. doi:10.1038/sj.bjp.0705117. PMC 1573728. PMID 12642396. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573728.  edit
  2. ^ Shin, E. J.; Nah, S. Y.; Kim, W. K.; Ko, K. H.; Jhoo, W. K.; Lim, Y. K.; Cha, J. Y.; Chen, C. F. et al. (2005). "The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan". British Journal of Pharmacology 144 (7): 908–918. doi:10.1038/sj.bjp.0705998. PMC 1576070. PMID 15723099. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1576070.  edit
  3. ^ Chou, Y. C.; Liao, J. F.; Chang, W. Y.; Lin, M. F.; Chen, C. F. (1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain research 821 (2): 516–519. PMID 10064839.  edit
v · d · eCough and cold preparations (R05)
Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
Acetyldihydrocodeine • Benzylmorphine • Codeine • Dextromethorphan • Diacetylmorphine • Dihydrocodeine • Dimemorfan • Droxypropine • Ethylmorphine • Hydrocodone • Hydromorphone • Isoaminile • Laudanum • Levomethadone • Levopropoxyphene • Methadone • Nicocodeine • Nicodicodeine • Normethadone • Noscapine • Pholcodine • Thebacon • Tipepidine • Zipeprol
Other

M: RES

anat(n, x, l, c)/phys/devp

noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)
Stub icon This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.