- Dornase alfa
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Dornase Alfa Clinical data Trade names Pulmozyme AHFS/Drugs.com monograph MedlinePlus a694002 Pregnancy cat. B Legal status ? Routes inhalation Identifiers CAS number 9003-98-9 
ATC code R05CB13 DrugBank DB00003 UNII 953A26OA1Y 
Chemical data Formula ? 
(what is this?) alfa (verify)
A box of Pulmozyme
Dornase alfa (proprietary name Pulmozyme from Genentech) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus of cystic fibrosis patients and reduces viscosity in the lungs, promoting improved clearance of secretions. This protein therapeutic agent is produced in Chinese hamster ovary cells.
Dornase alfa is the most recent therapeutic agent developed with this basic mechanism of action. Prior to the cloning of the human enzyme, bovine DNase I was on the market for many years, though its utility was limited by the inherent antigenic response to a cow protein in the lungs of patients. Other DNases, such as DNase II, have therapeutic potential as well, but as of yet no further DNases have been brought to market for cystic fibrosis.
Dornase alfa is an orphan drug.[1]
References
- ^ Collier, Joe (1 September 1995). "Dornase-alfa and orphan drugs". The Lancet 346 (8975): 633. doi:10.1016/S0140-6736(95)91460-9.
Cough and cold preparations (R05) Expectorants Mucolytics Acetylcysteine • Ambroxol • Bromhexine • Carbocisteine • Domiodol • Dornase alfa • Eprazinone • Erdosteine • Letosteine • Mesna • Neltenexine • Sobrerol • Stepronin • TioproninCough suppressants Acetyldihydrocodeine • Benzylmorphine • Codeine • Dextromethorphan • Diacetylmorphine • Dihydrocodeine • Dimemorfan • Droxypropine • Ethylmorphine • Hydrocodone • Hydromorphone • Isoaminile • Laudanum • Levomethadone • Levopropoxyphene • Methadone • Nicocodeine • Nicodicodeine • Normethadone • Noscapine • Pholcodine • Thebacon • Tipepidine • ZipeprolOtherBenzonatate • Benproperine • Bibenzonium bromide • Butamirate • Clobutinol • Clofedanol • Cloperastine • Diphenhydramine • Dibunate • Dimethoxanate • Dropropizine • Fedrilate • Glaucine • Levodropropizine • Meprotixol • Morclofone • Nepinalone • Oxolamine • Oxeladin • Pentoxyverine • Pipazetate • Prenoxdiazine • PiperidioneCategories:- Drugs acting on the respiratory system
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