- Warthin's tumor
Warthin's tumor Classification and external resources
This Warthin's tumor presented as a parotid mass in a middle-aged male, who underwent superficial parotidectomy. The tumor, at the right of the image, is well-demarcated from the adjacent parotid tissue and tends to shell out from it.
ICD-10 D11 ICD-9 210.2 ICD-O: 8561/0 DiseasesDB 31941 eMedicine plastic/371 MeSH D000235
- Not to be confused with Wharton's duct (submandibular duct)
Warthin's tumor primarily affects older individuals (age 60–70 years). There is a slight female predilection according to recent studies, but historically it has been associated with a strong male predilection. This change is possibly due to the tumor's association with cigarette smoking and the growing use of cigarettes by women. The tumor is slow growing, painless, and usually appears in the tail of the parotid gland near the angle of the mandible. In 5–14% of cases, Warthin's tumor is bilateral, but the two masses usually are at different times. Warthin's tumor is highly unlikely to become malignant.
The appearance of this tumor under the microscope is unique. There are cystic spaces surrounded by two uniform rows of cells with centrally placed pyknotic nuclei. The cystic spaces have epithelium referred to as papillary infoldings that protrude into them. Additionally, the epithelium has lymphoid stroma with germinal center formation.
Most of these tumors are treated with surgical removal. It is non recurrent .
Intermediate magnification micrograph of a Warthin tumor.
High magnification micrograph of a Warthin tumor showing the characteristic bilayered epithelium.
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
Glandular and epithelial neoplasms (ICD-O 8010-8589) Epithelium GlandsOther/multipleAdnexal and
skin appendage (8390-8429)Cystic, mucinous,
and serous (8440-8499)Cystic generalSerousDuctal, lobular,
and medullary (8500-8549)Lobular carcinoma in situ · Invasive lobular carcinomaAcinar cell (8550-8559)
OtherComplex epithelial (8560-8589)Warthin's tumor · Thymomasee also Template:Epithelium and epithelial tissue Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210) Oral cancer
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