Paget's disease of the breast
- Paget's disease of the breast
Paget's disease of the breast, also known as Paget's disease of the nipple, is a condition that outwardly may have the appearance of eczema - with skin changes involving the nipple of the breast. Because of its seemingly innocuous and surface appearance, it often presents late, but it is a condition that may be fatal.
Extramammary Paget's disease (EMPD) has the same histologic features as Paget's disease of the breast but different locations.
The first symptom is usually an eczema-like rash, usually only affecting one nipple. The skin of the nipple and areola may be red and inflamed. Some women have an itching or burning sensation. Fluid (discharge) may leak from the abnormal area of cells. The nipple may turn inwards (be inverted). There may or may not be a lump in the breast, and there may be redness, oozing and crusting, and a sore that does not heal.
Recommended tests are a mammogram and a biopsy to confirm the diagnosis, and cytology may also be helpful.
Paget's disease of the breast is a type of cancer of the breast. Treatment usually involves some kind of mastectomy to surgically remove the tumour. Chemotherapy and/or radiotherapy may be necessary.
The condition is named after Sir James Paget, an English surgeon who first described it in 1874.
* [http://www.cancer.gov/cancertopics/factsheet/Sites-Types/pagets-breast National Cancer Institute fact sheet]
* [http://www.snopes.com/medical/disease/paget.asp Snopes]
* [http://www.mayoclinic.com/health/pagets-disease-of-the-breast/DS00771 Overview at mayoclinic.com]
* [http://etmd.medctr.ucla.edu/ETMD%2Fmd%20info%2Fphotos%2Fpaget.html Image at medctr.ucla.edu]
Look at other dictionaries:
Paget's disease of the breast — The combination of scaly skin changes of the nipple resembling eczema and an underlying cancer of the breast. The nipple is inflamed because of the presence of Paget s cells. These large irregular cells are themselves not cancerous, but they are… … Medical dictionary
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Paget's disease — n. 1. a disease that deforms and weakens bones, in which rapid decalcification is followed by excessive calcification 2. a type of cancer usually involving the breast s larger ducts, areola, and nipple … English World dictionary