Mucoepidermoid carcinoma

Mucoepidermoid carcinoma
Mucoepidermoid carcinoma
Classification and external resources

Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
ICD-O: 8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in children. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.

Mucicarmine staining is one stain used by pathologist for detection.[2]

Contents

Epidemiology

Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]

Clinical Features

Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.

Histology

This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Molecular biology

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 (PMID:16444749).

Prognosis

Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.

Additional images

  • Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.

  • Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. The same lesion as shown in a filename "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain.

  • Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.

References

  1. ^ Elsevier Article Locator
  2. ^ Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
  3. ^ "Melnick M., Sedghizadeh P. S., Allen C. M., Jaskoll T.". Experimental and Molecular Pathology. 10 November 2011. doi:doi:10.1016/j.yexmp.2011.10.011. http://www.sciencedirect.com/science/article/pii/S0014480011001869. 

External links

v · d · eGlandular and epithelial neoplasms (ICD-O 8010-8589)
Epithelium
Papilloma/carcinoma
(8010-8139)
Glands
Renal cell carcinoma · Endometrioid tumor · Renal oncocytoma
Other/multiple
sweat gland (Hidrocystoma, Syringoma) · Syringocystadenoma papilliferum
Cystic general
Serous
Ovarian serous cystadenoma/Pancreatic serous cystadenoma/Serous cystadenocarcinoma/Papillary serous cystadenocarcinoma
Lobular carcinoma in situ · Invasive lobular carcinoma
Acinar cell (8550-8559)
Other
Complex epithelial (8560-8589)
see also Template:Epithelium and epithelial tissue
v · d · eTumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)
Oral cancer
malignant epithelial tumors (Acinic cell carcinoma, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary duct carcinoma, Epithelial-myoepithelial carcinoma)
benign epithelial tumors (Pleomorphic adenoma, Warthin's tumor)

M: MOU

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