Mucoepidermoid carcinoma

Mucoepidermoid carcinoma
Mucoepidermoid carcinoma
Classification and external resources

Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
ICD-O: 8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in children. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.

Mucicarmine staining is one stain used by pathologist for detection.[2]



Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]

Clinical Features

Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.


This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Molecular biology

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 (PMID:16444749).


Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.

Additional images


External links

Wikimedia Foundation. 2010.

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