Mucoepidermoid carcinoma

Mucoepidermoid carcinoma
Mucoepidermoid carcinoma
Classification and external resources

Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
ICD-O: 8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in children. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.

Mucicarmine staining is one stain used by pathologist for detection.[2]

Contents

Epidemiology

Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]

Clinical Features

Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.

Histology

This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Molecular biology

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 (PMID:16444749).

Prognosis

Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.

Additional images

References

External links



Wikimedia Foundation. 2010.

Нужно решить контрольную?

Look at other dictionaries:

  • mucoepidermoid carcinoma — a malignant epithelial tumor of glandular tissue, especially the salivary glands, characterized by acini with mucus producing cells and by the presence of malignant squamous elements; it may occur as a low, intermediate, or high grade malignancy …   Medical dictionary

  • Carcinoma mucoepidermoide — Saltar a navegación, búsqueda Carcinoma mucoepidermoide Clasificación y recursos externos Aviso médico …   Wikipedia Español

  • mucoepidermoid — Denoting a mixture of mucus secreting and epithelial cells, as in m. carcinoma. * * * mu·co·epi·der·moid .myü kō .ep ə dər .mȯid adj of, relating to, or consisting of both mucous and squamous epithelial cells esp being a tumor of the salivary… …   Medical dictionary

  • carcinoma mucoepidermoide — Eng. Mucoepidermoid carcinoma Variante del carcinoma de células escamosas que afecta a personas mayores de 60 años, formado por células con capacidad de producción mucosa y de mayor agresividad que el carcinoma de células escamosas.Puede invadir… …   Diccionario de oftalmología

  • carcinoma — Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell c.); the most commonly occurring kind of cancer. [G. karkinoma, fr. karkinos, cancer, + oma, tumor] Like other …   Medical dictionary

  • Carcinoma — Infobox Disease Name = Carcinoma Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = 8010/3 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D002277 A carcinoma is any malignant cancer that arises from epithelial cells. Carcinomas invade… …   Wikipedia

  • mucoepidermoid tumor — see under carcinoma …   Medical dictionary

  • Squamous-cell carcinoma — Squamous cell carcinoma, NOS Classification and external resources SCC of the skin tends to arise from pre malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). ICD 10 …   Wikipedia

  • Renal cell carcinoma — For other uses, see RCC (disambiguation). Main article: Kidney cancer Renal cell carcinoma Classification and external resources Micrograph of the most common t …   Wikipedia

  • Mammary ductal carcinoma — Ductal Carcinoma Classification and external resources Histopathologic image from ductal cell carcinoma in situ (DCIS) of breast. Hematoxylin eosin stain. ICD 10 C …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”