Nafenopin

Nafenopin

IUPAC name 2-Methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
Identifiers
CAS number	3771-19-5^Y
PubChem	19592
ChemSpider	18456
KEGG	C11371^Y
Jmol-3D images	Image 1
SMILES O=C(O)C(Oc1ccc(cc1)C3c2ccccc2CCC3)(C)C
InChI InChI=StdInChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22) Key: XJGBDJOMWKAZJS-UHFFFAOYSA-N InChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22) InChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22) Key: XJGBDJOMWKAZJS-UHFFFAOYSA-N
Properties
Molecular formula	C₂₀H₂₂O₃
Molar mass	310.39 g mol⁻¹
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Nafenopin is a hypolipidemic agent.

Synthesis

Nafenopin can be prepared from 1-tetralinol:^[1]

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe • SCH-48461

Bile acid sequestrants/resins (LDL)	Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam

Statins (HMG-CoA reductase, LDL)	Simvastatin^# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox

Fibrates (PPAR)	Clofibrate^‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† • Dalcetrapib • Evacetrapib • Torcetrapib^§

Combinations

Other

Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat^§ • Alipogene tiparvovec

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

Categories:

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

List of IARC Group 2B carcinogens — Substances, mixtures and exposure circumstances in this list have been classified by the IARC as Group 2B: The agent (mixture) is possibly carcinogenic to humans. The exposure circumstance entails exposures that are possibly carcinogenic to… … Wikipedia