Cysteine—tRNA ligase

cysteine-tRNA ligase
Identifiers
EC number	6.1.1.16
CAS number	37318-56-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a cysteine-tRNA ligase (EC 6.1.1.16) is an enzyme that catalyzes the chemical reaction

ATP + L-cysteine + tRNACys $\rightleftharpoons$ AMP + diphosphate + L-cysteinyl-tRNACys

The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1LI5, 1LI7, and 1U0B.

References

• McCorquodale DJ (1964). "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coli". Biochim. Biophys. Acta 91: 541–548. PMID 14262440. 

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