- Proline-tRNA ligase
In
enzymology , a proline-tRNA ligase (EC number|6.1.1.15) is anenzyme that catalyzes thechemical reaction :ATP + L-proline + tRNAPro AMP + diphosphate + L-prolyl-tRNAPro
The 3 substrates of this enzyme are ATP,
L-proline , andtRNA(Pro) , whereas its 3 products are AMP,diphosphate , andL-prolyl-tRNA(Pro) .This enzyme belongs to the family of
ligase s, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. This enzyme participates inarginine and proline metabolism andaminoacyl-trna biosynthesis .tructural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1H4Q, PDB link|1H4S, PDB link|1H4T, PDB link|1HC7, PDB link|1NJ1, PDB link|1NJ2, PDB link|1NJ5, PDB link|1NJ6, PDB link|1NJ8, PDB link|2I4L, PDB link|2I4M, PDB link|2I4N, PDB link|2I4O, PDB link|2J3L, and PDB link|2J3M.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|9055-68-9."Gene Ontology (GO) codes
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