Serine-tRNA ligase

Serine-tRNA ligase

In enzymology, a serine-tRNA ligase (EC number|6.1.1.11) is an enzyme that catalyzes the chemical reaction

:ATP + L-serine + tRNASer ightleftharpoons AMP + diphosphate + L-seryl-tRNASer

The 3 substrates of this enzyme are ATP, L-serine, and tRNA(Ser), whereas its 3 products are AMP, diphosphate, and L-seryl-tRNA(Ser).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-serine:tRNASer ligase (AMP-forming). Other names in common use include seryl-tRNA synthetase, SerRS, seryl-transfer ribonucleate synthetase, seryl-transfer RNA synthetase, seryl-transfer ribonucleic acid synthetase, and serine translase. This enzyme participates in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1SER, PDB link|1SES, PDB link|1SET, PDB link|1SRY, PDB link|1WLE, PDB link|2CIM, PDB link|2CJ9, PDB link|2CJA, PDB link|2CJB, PDB link|2DQ0, PDB link|2DQ1, PDB link|2DQ2, and PDB link|2DQ3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-48-7."

Gene Ontology (GO) codes


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