Lysine-tRNA ligase

In enzymology, a lysine-tRNA ligase (EC number|6.1.1.6) is an enzyme that catalyzes the chemical reaction

:ATP + L-lysine + tRNALys $ightleftharpoons$ AMP + diphosphate + L-lysyl-tRNALys

The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Lys), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Lys).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNALys ligase (AMP-forming). Other names in common use include lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine translase. This enzyme participates in 3 metabolic pathways: lysine biosynthesis, aminoacyl-trna biosynthesis, and amyotrophic lateral sclerosis (als).

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BBU, PDB link|1BBW, PDB link|1E1O, PDB link|1E1T, PDB link|1E22, PDB link|1E24, PDB link|1IRX, PDB link|1KRS, PDB link|1KRT, and PDB link|1LYL.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-26-9."

Gene Ontology (GO) codes