Acetyl-CoA carboxylase

Acetyl-CoA carboxylase


In muscle cells, the function of ACAC is to regulate the fatty mechanism. When the enzyme is active, the product, malonyl-CoA is produced and inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of the fatty acid in mitochondria.


The inactive dimer form of this enzyme is induced to polymerize by citrate, resulting in the active polymer form.

The activity of the enzyme is controlled by the reversible phosphorylation. The activities of the enzyme is inhibited if phosphorylated; the phosphorylation takes place when the hormones, glucagon or epinephrine bind to the receptors or the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase.

The presence of fatty acid inhibits the activities of the enzyme.

When insulin binds to its receptors of the cell, it activates a phosphatase to dephosphorylate the enzyme; the activities of the acetyl-CoA carboxylase is thus enhanced.

Clinical implications

Bacterial Acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity and antibiotic drugs.

ee also

* Malonyl-CoA decarboxylase



Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Acetyl-CoA-Carboxylase — Masse/Länge Primärstruktur 2346 Aminosäuren …   Deutsch Wikipedia

  • (acetyl-CoA carboxylase) kinase — In enzymology, a [acetyl CoA carboxylase] kinase (EC number| is an enzyme that catalyzes the chemical reaction:ATP + [acetyl CoA carboxylase] ightleftharpoons ADP + [acetyl CoA carboxylase] phosphateThus, the two substrates of this… …   Wikipedia

  • (acetyl-CoA carboxylase)-phosphatase — In enzymology, a [acetyl CoA carboxylase] phosphatase (EC number| is an enzyme that catalyzes the chemical reaction: [acetyl CoA carboxylase] phosphate + H2O ightleftharpoons [acetyl CoA carboxylase] + phosphateThus, the two substrates… …   Wikipedia

  • acetyl-CoA carboxylase — ac·e·tyl CoA car·box·yl·ase (asґə təl ) (as″ə tēlґko aґ kahr bokґsə lās) [EC] a biotin containing enzyme of the ligase class that catalyzes the carboxylation of acetyl coenzyme A to form malonyl… …   Medical dictionary

  • Biotin-(acetyl-CoA-carboxylase) ligase — In enzymology, a biotin [acetyl CoA carboxylase] ligase (EC number| is an enzyme that catalyzes the chemical reaction:ATP + biotin + apo [acetyl CoA:carbon dioxide ligase (ADP forming)] ightleftharpoons AMP + diphosphate + [acetyl… …   Wikipedia

  • Acetyl-CoA — Chembox new ImageFile = Acetyl CoA 2D.svg ImageSize = 350px ImageFile2 = Acetyl CoA 3D balls.png IUPACName = OtherNames = Section1 = Chembox Identifiers CASNo = 72 89 9 PubChem = 181 SMILES = O=C(NCCSC(=O)C)CCNC (=O) [C@H] (O)C(C)(C)… …   Wikipedia

  • acetyl-CoA — Condensation product of coenzyme A and acetic acid, symbolized as CoAS∼COCH3; intermediate in transfer of two carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis. SYN: acetyl coenzyme A …   Medical dictionary

  • Propionyl-CoA carboxylase — PCCA redirects here. For other uses, see PCCA (disambiguation). Propionyl CoA carboxylase Identifiers EC number CAS number …   Wikipedia

  • Methylcrotonyl-CoA carboxylase — methylcrotonoyl Coenzyme A carboxylase 1 (alpha) Identifiers Symbol MCCC1 Entrez 56922 HUGO …   Wikipedia

  • Methylcrotonoyl-CoA-Carboxylase — 1 (α Untereinheit) Masse/Länge Primärstruktur 725 AA …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”