Biotin-(acetyl-CoA-carboxylase) ligase

In enzymology, a biotin- [acetyl-CoA-carboxylase] ligase (EC number|6.3.4.15) is an enzyme that catalyzes the chemical reaction

:ATP + biotin + apo- [acetyl-CoA:carbon-dioxide ligase (ADP-forming)] $ightleftharpoons$ AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and ] , whereas its 3 products are AMP, diphosphate, and ] .

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo- [acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin- [acetyl-CoA carboxylase] synthetase, biotin- [acetyl coenzyme A carboxylase] synthetase, acetyl coenzyme A holocarboxylase synthetase, acetyl CoA holocarboxylase synthetase, biotin:apocarboxylase ligase, Biotin holoenzyme synthetase, and HCS. This enzyme participates in biotin metabolism.

tructural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BIA, PDB link|1BIB, PDB link|1HXD, PDB link|1WNL, PDB link|1WPY, PDB link|1WQ7, PDB link|1WQW, PDB link|1X01, PDB link|2CGH, PDB link|2DEQ, PDB link|2DJZ, PDB link|2DKG, PDB link|2DTH, PDB link|2DTI, PDB link|2DTO, PDB link|2DVE, PDB link|2DXT, PDB link|2DXU, PDB link|2DZ9, PDB link|2DZC, PDB link|2E10, PDB link|2E3Y, PDB link|2E41, PDB link|2E64, PDB link|2E65, PDB link|2EAY, PDB link|2EWN, PDB link|2FYK, and PDB link|2HNI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37340-95-7."

Gene Ontology (GO) codes