Biotin carboxylase

In enzymology, a biotin carboxylase (EC number|6.3.4.14) is an enzyme that catalyzes the chemical reaction

:ATP + biotin-carboxyl-carrier protein + CO₂ $ightleftharpoons$ ADP + phosphate + carboxybiotin-carboxyl-carrier protein

The 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO₂, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming). This enzyme is also called biotin carboxylase (component of acetyl CoA carboxylase). This enzyme participates in fatty acid biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BNC, PDB link|1DV1, PDB link|1DV2, PDB link|2GPS, and PDB link|2GPW.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-71-2."

Gene Ontology (GO) codes