Leucine-tRNA ligase

Leucine-tRNA ligase

In enzymology, a leucine-tRNA ligase (EC number|6.1.1.4) is an enzyme that catalyzes the chemical reaction

:ATP + L-leucine + tRNALeu ightleftharpoons AMP + diphosphate + L-leucyl-tRNALeu

The 3 substrates of this enzyme are ATP, L-leucine, and tRNA(Leu), whereas its 3 products are AMP, diphosphate, and L-leucyl-tRNA(Leu).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-leucine:tRNALeu ligase (AMP-forming). Other names in common use include leucyl-tRNA synthetase, leucyl-transfer ribonucleate synthetase, leucyl-transfer RNA synthetase, leucyl-transfer ribonucleic acid synthetase, leucine-tRNA synthetase, and leucine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WKB, PDB link|1WZ2, PDB link|2AJG, PDB link|2AJH, and PDB link|2AJI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-15-6."

Gene Ontology (GO) codes


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