- Leucine-tRNA ligase
In
enzymology , a leucine-tRNA ligase (EC number|6.1.1.4) is anenzyme that catalyzes thechemical reaction :ATP + L-leucine + tRNALeu AMP + diphosphate + L-leucyl-tRNALeu
The 3 substrates of this enzyme are ATP,
L-leucine , andtRNA(Leu) , whereas its 3 products are AMP,diphosphate , andL-leucyl-tRNA(Leu) .This enzyme belongs to the family of
ligase s, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-leucine:tRNALeu ligase (AMP-forming). Other names in common use include leucyl-tRNA synthetase, leucyl-transfer ribonucleate synthetase, leucyl-transfer RNA synthetase, leucyl-transfer ribonucleic acid synthetase, leucine-tRNA synthetase, and leucine translase. This enzyme participates invaline, leucine and isoleucine biosynthesis andaminoacyl-trna biosynthesis .tructural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WKB, PDB link|1WZ2, PDB link|2AJG, PDB link|2AJH, and PDB link|2AJI.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|9031-15-6."Gene Ontology (GO) codes
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