Tyrosine-tRNA ligase

In enzymology, a tyrosine-tRNA ligase (EC number|6.1.1.1) is an enzyme that catalyzes the chemical reaction

:ATP + L-tyrosine + RNA $ightleftharpoons$ AMP + triphosphate + L-tyrosyl-tRNATyr

The 3 substrates of this enzyme are ATP, L-tyrosine, and RNA, whereas its 3 products are AMP, triphosphate, and L-tyrosyl-tRNA(Tyr).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tyrosine:tRNATyr ligase (AMP-forming). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 34 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1H3E, PDB link|1J1U, PDB link|1JH3, PDB link|1JII, PDB link|1JIJ, PDB link|1JIK, PDB link|1JIL, PDB link|1N3L, PDB link|1NTG, PDB link|1Q11, PDB link|1TYA, PDB link|1TYB, PDB link|1TYC, PDB link|1TYD, PDB link|1U7D, PDB link|1U7X, PDB link|1VBM, PDB link|1VBN, PDB link|1WQ3, PDB link|1WQ4, PDB link|1X8X, PDB link|1Y42, PDB link|1ZH0, PDB link|1ZH6, PDB link|2AG6, PDB link|2CYA, PDB link|2CYB, PDB link|2CYC, PDB link|2DLC, PDB link|2HGZ, PDB link|2J5B, PDB link|2TS1, PDB link|3TS1, and PDB link|4TS1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-45-4."

Gene Ontology (GO) codes