DXP reductoisomerase

1-deoxy-D-xylulose 5-phosphate reductoisomerase
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol	DXP_reductoisom
Pfam	PF02670
Pfam clan	CL0063
InterPro	IPR013512
SCOP	1onn
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol	DXP_redisom_C
Pfam	PF08436
Pfam clan	CL0063
InterPro	IPR013644
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

DXP reductoisomerase or (1-deoxy-d-xylulose 5-phosphate reductoisomerase) is an enzyme that intraconverts 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate.^[1]

• 

  1-Deoxy-D-xylulose 5-phosphate

• 

  2-C-methylerythritol 4-phosphate

It is classified under EC 1.1.1.267.

It is part of the non-mevalonate pathway, and it is inhibited by fosmidomycin.

It is normally abbreviated DXR, but it is sometimes named IspC.

This enzyme is responsible for terpenoid biosynthesis in some organisms.^[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.

External links

• MeSH DXP+reductoisomerase

References

1. ^ ^{a b} Takahashi S, Kuzuyama T, Watanabe H, Seto H (August 1998). "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9879–84. doi:10.1073/pnas.95.17.9879. PMC 21430. PMID 9707569. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21430. 

This article includes text from the public domain Pfam and InterPro IPR013512

This article includes text from the public domain Pfam and InterPro IPR013644

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.v · Categories: Protein families EC 1.1.1 Oxidoreductase stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Occold Thurston Hall Look at other dictionaries: DXP — may refer to DXP reductoisomerase, enzyme DXP synthase, enzyme Delta Xi Phi, sorority Class of processor made by Icera Record label associated with DeeExpus This disambiguation page lists articles associated with the same title. If an …   Wikipedia DXP synthase — 1 Deoxy D xylulose 5 phosphate DXP synthase is an enzyme in the non mevalonate pathway. It generates 1 deoxy D xylulose 5 phosphate from pyruvate and glyceraldehyde 3 phosphate. It is classified under EC 2.2.1.7 …   Wikipedia Non-mevalonate pathway — The non mevalonate pathway or 2 C methyl D erythritol 4 phosphate/1 deoxy D xylulose 5 phosphate pathway (MEP/DOXP pathway) of isoprenoid biosynthesis is an alternative metabolic pathway leading to the formation of isopentenyl pyrophosphate (IPP) …   Wikipedia 2-C-methylerythritol 4-phosphate — Chembox new ImageFile=MEP.png ImageSize= IUPACName=2,3,4 trihydroxy 3 methylbutyl dihydrogen phosphate OtherNames=MEP Section1= Chembox Identifiers CASNo= PubChem=443198 SMILES=CC(CO)(C(COP(=O)(O)O)O)O Section2= Chembox Properties… …   Wikipedia Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia 1-Deoxy-D-xylulose 5-phosphate — IUPAC name (2,3 dihydroxy 4 oxopentyl) dihydrogen phosphate …   Wikipedia Alcohol dehydrogenase — Crystallographic structure of the homodimer of human ADH5.[1] Identifiers …   Wikipedia Oxidoreductase — In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). This… …   Wikipedia Glucose oxidase — Template:The Heart and Smiley Identifiers EC number 1.1.3.4 …   Wikipedia Malate dehydrogenase — Structure of the protein with attached sugars Identifiers EC number …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”