DXP reductoisomerase

1-deoxy-D-xylulose 5-phosphate reductoisomerase
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol	DXP_reductoisom
Pfam	PF02670
Pfam clan	CL0063
InterPro	IPR013512
SCOP	1onn
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol	DXP_redisom_C
Pfam	PF08436
Pfam clan	CL0063
InterPro	IPR013644
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

DXP reductoisomerase or (1-deoxy-d-xylulose 5-phosphate reductoisomerase) is an enzyme that intraconverts 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate.^[1]

• 

  1-Deoxy-D-xylulose 5-phosphate

• 

  2-C-methylerythritol 4-phosphate

It is classified under EC 1.1.1.267.

It is part of the non-mevalonate pathway, and it is inhibited by fosmidomycin.

It is normally abbreviated DXR, but it is sometimes named IspC.

This enzyme is responsible for terpenoid biosynthesis in some organisms.^[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.

External links

• MeSH DXP+reductoisomerase

References

1. ^ ^{a b} Takahashi S, Kuzuyama T, Watanabe H, Seto H (August 1998). "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9879–84. doi:10.1073/pnas.95.17.9879. PMC 21430. PMID 9707569. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21430. 

This article includes text from the public domain Pfam and InterPro IPR013512

This article includes text from the public domain Pfam and InterPro IPR013644

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