Mannitol dehydrogenase (cytochrome)

mannitol dehydrogenase (cytochrome)
Identifiers
EC number	1.1.2.2
CAS number	37250-78-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a mannitol dehydrogenase (cytochrome) (EC 1.1.2.2) is an enzyme that catalyzes the chemical reaction

D-mannitol + ferricytochrome c $\rightleftharpoons$ D-fructose + ferrocytochrome c

Thus, the two substrates of this enzyme are D-mannitol and ferricytochrome c, whereas its two products are D-fructose and ferrocytochrome c.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is D-mannitol:ferricytochrome-c 2-oxidoreductase. This enzyme is also called polyol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

References

• ARCUS AC, EDSON NL (1956). "Polyol dehydrogenases. 2. The polyol dehydrogenases of Acetobacter suboxydans and Candida utilis". Biochem. J. 64 (3): 385–94. PMC 1199748. PMID 13373782. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1199748. 
• Cho NC, Kim K and Jhon DY (1990). "Purification and characterization of polyol dehydrogenase from Gluconobacter melanogenus". Han'guk Saenghwa Hakhaochi 23: 172–178.