AKR1C1

Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), also known as AKR1C1, is a human gene.cite web | title = Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1645| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.cite web | title = Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1645| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ciaccio PJ, Jaiswal AK, Tew KD |title=Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15558–62 |year= 1994 |pmid= 7515059 |doi=
*cite journal | author=Khanna M, Qin KN, Cheng KC |title=Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 41–6 |year= 1995 |pmid= 7626489 |doi=
*cite journal | author=Khanna M, Qin KN, Klisak I, "et al." |title=Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 2 |pages= 588–90 |year= 1995 |pmid= 7789999 |doi=
*cite journal | author=Ciaccio PJ, Tew KD |title=cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. |journal=Biochim. Biophys. Acta |volume=1186 |issue= 1-2 |pages= 129–32 |year= 1994 |pmid= 8011662 |doi=
*cite journal | author=Lou H, Hammond L, Sharma V, "et al." |title=Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. |journal=J. Biol. Chem. |volume=269 |issue= 11 |pages= 8416–22 |year= 1994 |pmid= 8132567 |doi=
*cite journal | author=Deyashiki Y, Ogasawara A, Nakayama T, "et al." |title=Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. |journal=Biochem. J. |volume=299 ( Pt 2) |issue= |pages= 545–52 |year= 1994 |pmid= 8172617 |doi=
*cite journal | author=Qin KN, New MI, Cheng KC |title=Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. |journal=J. Steroid Biochem. Mol. Biol. |volume=46 |issue= 6 |pages= 673–9 |year= 1994 |pmid= 8274401 |doi=
*cite journal | author=Stolz A, Hammond L, Lou H, "et al." |title=cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. |journal=J. Biol. Chem. |volume=268 |issue= 14 |pages= 10448–57 |year= 1993 |pmid= 8486699 |doi=
*cite journal | author=Hara A, Matsuura K, Tamada Y, "et al." |title=Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. |journal=Biochem. J. |volume=313 ( Pt 2) |issue= |pages= 373–6 |year= 1996 |pmid= 8573067 |doi=
*cite journal | author=O'connor T, Ireland LS, Harrison DJ, Hayes JD |title=Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. |journal=Biochem. J. |volume=343 Pt 2 |issue= |pages= 487–504 |year= 1999 |pmid= 10510318 |doi=
*cite journal | author=Nishizawa M, Nakajima T, Yasuda K, "et al." |title=Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. |journal=Genes Cells |volume=5 |issue= 2 |pages= 111–25 |year= 2000 |pmid= 10672042 |doi=
*cite journal | author=Zhang Y, Dufort I, Rheault P, Luu-The V |title=Characterization of a human 20alpha-hydroxysteroid dehydrogenase. |journal=J. Mol. Endocrinol. |volume=25 |issue= 2 |pages= 221–8 |year= 2000 |pmid= 11013348 |doi=
*cite journal | author=Nahoum V, Gangloff A, Legrand P, "et al." |title=Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42091–8 |year= 2001 |pmid= 11514561 |doi= 10.1074/jbc.M105610200
*cite journal | author=Chen CY, Hsu CP, Hsu NY, "et al." |title=Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 515–9 |year= 2002 |pmid= 11956619 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yang MD, Wu CC, Chiou SH, "et al." |title=Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma. |journal=Oncol. Rep. |volume=10 |issue= 2 |pages= 271–6 |year= 2003 |pmid= 12579257 |doi=
*cite journal | author=Nakajima T, Yasuda K, Nishizawa M, "et al." |title=Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua. |journal=Endocr. J. |volume=50 |issue= 1 |pages= 105–11 |year= 2003 |pmid= 12733716 |doi=
*cite journal | author=Couture JF, Legrand P, Cantin L, "et al." |title=Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. |journal=J. Mol. Biol. |volume=331 |issue= 3 |pages= 593–604 |year= 2003 |pmid= 12899831 |doi=
*cite journal | author=Agapova OA, Yang P, Wang WH, "et al." |title=Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes. |journal=Neurobiol. Dis. |volume=14 |issue= 1 |pages= 63–73 |year= 2003 |pmid= 13678667 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462

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