Vitamin K epoxide reductase
- Vitamin K epoxide reductase
protein
name=vitamin K epoxide reductase complex, subunit 1
caption=
width=
HGNCid=23663
Symbol=VKORC1
AltSymbols=VKCFD2
EntrezGene=79001
OMIM=
RefSeq=NM_024006
UniProt=
PDB=
ECnumber=
Chromosome=16
Arm=p
Band=11.2
LocusSupplementaryData=
Vitamin K epoxide reductase (VKOR) is an enzyme (EC number|1.1.4.1) that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid. Its C1 subunit (VKORC1) is the target of anticoagulant warfarin. [Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW. Identification of the gene for vitamin K epoxide reductase. "Nature" 2004;427(6974):541-4. PMID 14765195.] [Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J. Mutations in "VKORC1" cause warfarin resistance and multiple coagulation factor deficiency type 2. "Nature" 2004;427(6974):537-41. PMID 14765194.]
References
See also
* Oxidoreductase
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