Vitamin-K-epoxide reductase (warfarin-sensitive)
- Vitamin-K-epoxide reductase (warfarin-sensitive)
In enzymology, a vitamin-K-epoxide reductase (warfarin-sensitive) (EC number|1.1.4.1) is an enzyme that catalyzes the chemical reaction
:2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Thus, the two substrates of this enzyme are 2-methyl-3-phytyl-1,4-naphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase. This enzyme participates in biosynthesis of steroids. At least one compound, Warfarin is known to inhibit this enzyme.
References
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|55963-40-1."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
Warfarin — This article is about the drug with the brandname Coumadin. For the anticoagulant rodenticide poisons often called coumarins or coumadins , see 4 hydroxycoumarins. Warfarin … Wikipedia
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia
Alcohol dehydrogenase — Crystallographic structure of the homodimer of human ADH5.[1] Identifiers … Wikipedia
Corticosteroid 11-beta-dehydrogenase isozyme 2 — Hydroxysteroid (11 beta) dehydrogenase 2 Identifiers Symbols HSD11B2; AME; AME1; HSD11K; HSD2; SDR9C3 External IDs … Wikipedia
VKORC1 — Vitamin K epoxide reductase complex, subunit 1, also known as VKORC1, is a human gene.cite web | title = Entrez Gene: VKORC1 vitamin K epoxide reductase complex, subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView … Wikipedia
Personalized medicine — is the concept that information about an patient s genotype or gene expression profile could be used to tailor medical care to an individual s needs. Such information could be used to help stratify disease status, select between different… … Wikipedia
