BAG1

BAG1

BCL2-associated athanogene, also known as BAG1, is a human gene.

PBB_Summary
section_title =
summary_text = The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.cite web | title = Entrez Gene: BAG1 BCL2-associated athanogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tang SC |title=BAG-1, an anti-apoptotic tumour marker. |journal=IUBMB Life |volume=53 |issue= 2 |pages= 99–105 |year= 2003 |pmid= 12049201 |doi=
*cite journal | author=Clemo NK, Arhel NJ, Barnes JD, "et al." |title=The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 676–8 |year= 2005 |pmid= 16042572 |doi= 10.1042/BST0330676
*cite journal | author=Gehring U |title=Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms. |journal=Cell Stress Chaperones |volume=11 |issue= 4 |pages= 295–303 |year= 2007 |pmid= 17278878 |doi=
*cite journal | author=Takayama S, Sato T, Krajewski S, "et al." |title=Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. |journal=Cell |volume=80 |issue= 2 |pages= 279–84 |year= 1995 |pmid= 7834747 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zeiner M, Gehring U |title=A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11465–9 |year= 1996 |pmid= 8524784 |doi=
*cite journal | author=Wang HG, Takayama S, Rapp UR, Reed JC |title=Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7063–8 |year= 1996 |pmid= 8692945 |doi=
*cite journal | author=Takayama S, Kochel K, Irie S, "et al." |title=Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. |journal=Genomics |volume=35 |issue= 3 |pages= 494–8 |year= 1996 |pmid= 8812483 |doi= 10.1006/geno.1996.0389
*cite journal | author=Bardelli A, Longati P, Albero D, "et al." |title=HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. |journal=EMBO J. |volume=15 |issue= 22 |pages= 6205–12 |year= 1997 |pmid= 8947043 |doi=
*cite journal | author=Takayama S, Bimston DN, Matsuzawa S, "et al." |title=BAG-1 modulates the chaperone activity of Hsp70/Hsc70. |journal=EMBO J. |volume=16 |issue= 16 |pages= 4887–96 |year= 1997 |pmid= 9305631 |doi= 10.1093/emboj/16.16.4887
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Packham G, Brimmell M, Cleveland JL |title=Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. |journal=Biochem. J. |volume=328 ( Pt 3) |issue= |pages= 807–13 |year= 1998 |pmid= 9396724 |doi=
*cite journal | author=Matsuzawa S, Takayama S, Froesch BA, "et al." |title=p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. |journal=EMBO J. |volume=17 |issue= 10 |pages= 2736–47 |year= 1998 |pmid= 9582267 |doi= 10.1093/emboj/17.10.2736
*cite journal | author=Kullmann M, Schneikert J, Moll J, "et al." |title=RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14620–5 |year= 1998 |pmid= 9603979 |doi=
*cite journal | author=Liu R, Takayama S, Zheng Y, "et al." |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16985–92 |year= 1998 |pmid= 9642262 |doi=
*cite journal | author=Takayama S, Krajewski S, Krajewska M, "et al." |title=Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. |journal=Cancer Res. |volume=58 |issue= 14 |pages= 3116–31 |year= 1998 |pmid= 9679980 |doi=
*cite journal | author=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781–6 |year= 1999 |pmid= 9873016 |doi=
*cite journal | author=Yang X, Pater A, Tang SC |title=Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. |journal=Oncogene |volume=18 |issue= 32 |pages= 4546–53 |year= 1999 |pmid= 10467399 |doi= 10.1038/sj.onc.1202843
*cite journal | author=Schneikert J, Hübner S, Martin E, Cato AC |title=A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 929–40 |year= 1999 |pmid= 10477749 |doi=
*cite journal | author=Lüders J, Demand J, Höhfeld J |title=The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4613–7 |year= 2000 |pmid= 10671488 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • bag — bag1 W2S1 [bæg] n ▬▬▬▬▬▬▬ 1¦(container)¦ 2¦(amount)¦ 3 old/stupid bag 4¦(a lot of something)¦ 5 pack your bags 6¦(eyes)¦ 7 a bag of bones 8 in the bag 9¦(trousers)¦ …   Dictionary of contemporary English

  • bag — bag1 [ bæg ] noun count *** 1. ) a container made of paper, plastic, or cloth, used for carrying or storing things: Put your dirty clothes in the plastic bag. He was weighed down by shopping bags. a golf bag a ) the things in a bag, or the amount …   Usage of the words and phrases in modern English

  • Muscle spindle — Latin fusus neuromuscularis Code TH H3.11.06.0.00018 Muscle spindles are sensory receptors within the belly of a muscle, which primarily detect changes in the length of this muscle. They convey length information to the central nervous system via …   Wikipedia

  • Gamma motoneuron — Neuron: Gamma motorneuron A muscle spindle, with γ motor and Ia sensory fibers NeuroLex ID …   Wikipedia

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • BAG4 — BCL2 associated athanogene 4, also known as BAG4, is a human gene.cite web | title = Entrez Gene: BAG4 BCL2 associated athanogene 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9530| accessdate = ] PBB… …   Wikipedia

  • BAG5 — BCL2 associated athanogene 5, also known as BAG5, is a human gene.cite web | title = Entrez Gene: BAG5 BCL2 associated athanogene 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9529| accessdate = ] PBB… …   Wikipedia

  • Nuclear bag fiber — Latin myofibra sacculiformis Code TH H3.03.00.0.00013 A nuclear bag fiber is a type of intrafusal muscle fiber that lies in the center of a muscle spindle. Each has a large number of nuclei concentrated in bags and they cau …   Wikipedia

  • Lian, Batangas — Infobox Philippine municipality sealfile = Ph seal Lian Batangas.jpg infoboxtitle = Municipality of Lian, Batangas locatormapfile = Ph locator batangas lian.png caption = Map of Batangas showing the location of Lian. region = CALABARZON (Region… …   Wikipedia

  • Glucocorticoid receptor — Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Crystallographic structures of the glucocorticoid receptor DNA binding domain (DBD, left, PDB 1R4O bound to DNA) and ligand bindin …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”