- Glycerol-3-phosphate dehydrogenase
Name=glycerol-3-phosphate dehydrogenase 1 (soluble)
Name=glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate (aka glycerone phosphate, outdated).
Older terms for glycerol-3-phosphate dehydrogenase include "alpha glycerol-3-phosphate dehydrogenase" (alphaGPDH) and "glycerolphosphate dehydrogenase" (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase (GAPDH) whose substrate is an aldehyde not an alcohol.
The reaction catalyzed by cytosolic GPDH is as follows:
The cytosolic together with the mitochondrial glycerol-3-phosphate dehydrogenase work in concert. Oxidation of cytoplasmic NADH by the cytosolic form of the enzyme creates glycerol-3-phosphate from dihydroxyacetone phosphate. Once the Glycerol-3-phosphate has moved through the Outer Mitochondrial Membrane it can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase. This differ as it is instead FADH2 linked. As a result there is a net loss in energy, comparable to 1 ATP. Illustrated here [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=glycerol-3-phosphate%20dehydrogenase&rid=stryer.figgrp.2548] .
* substrate pages: glycerol 3-phosphate, dihydroxyacetone phosphate
* related topics: glycerol phosphate shuttle, creatine kinase, glycolysis, gluconeogenesis
* equivalent entries: MeshName|alphaGPDH and [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=mesh&Cmd=ShowDetailView&TermToSearch=68050536 GPDH]
* Yeast genome database GO term: [http://db.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=4367 GPDH]
* enzyme no. GPnotebook|-2053504966
Look at other dictionaries:
glycerol-3-phosphate dehydrogenase — α Glycerol phosphate dehydrogenase; 3 phosphoglycerol dehydrogenase; a flavoenzyme that catalyzes the interconversion of dihydroxyacetone phosphate and sn glycerol 3 phosphate, with the participation of NAD+; its action provides the glycerol… … Medical dictionary
Glycerol-3-phosphate dehydrogenase (NAD+) — In enzymology, a glycerol 3 phosphate dehydrogenase (NAD+) (EC number|220.127.116.11) is an enzyme that catalyzes the chemical reaction:sn glycerol 3 phosphate + NAD+ ightleftharpoons glycerone phosphate + NADH + H+Thus, the two substrates of this… … Wikipedia
Glycerol-3-phosphate dehydrogenase (NAD(P)+) — In enzymology, a glycerol 3 phosphate dehydrogenase [NAD(P)+] (EC number|18.104.22.168) is an enzyme that catalyzes the chemical reaction:sn glycerol 3 phosphate + NAD(P)+ ightleftharpoons glycerone phosphate + NAD(P)H + H+The 3 substrates of this… … Wikipedia
Glycerol-1-phosphate dehydrogenase (NAD(P)+) — In enzymology, a glycerol 1 phosphate dehydrogenase [NAD(P)+] (EC number|22.214.171.1241) is an enzyme that catalyzes the chemical reaction:sn glycerol 1 phosphate + NAD(P)+ ightleftharpoons glycerone phosphate + NAD(P)H + H+The 3 substrates of this… … Wikipedia
glycerol-3-phosphate dehydrogenase (NAD+) — glyc·er·ol 3 phos·phate de·hy·dro·gen·ase (NAD+) (glisґər ol fosґfāt de hiґdro jən ās) [EC 126.96.36.199] a cytosolic enzyme of the oxidoreductase class that catalyzes the oxidation of glycerol 3 phosphate to dihydroxyacetone… … Medical dictionary
Glycerol 3-phosphate — Chembox new ImageFile = glycerol 3 phosphate.png ImageSize = 150px IUPACName = 1,2,3 Propanetriol, 1 (dihydrogen phosphate) OtherNames = Glycerol 1 phosphate Glycerophosphate α glycerolphosphate Section1 = Chembox Identifiers CASNo = 57 03 4… … Wikipedia
Glycerol-3-phosphate 1-dehydrogenase (NADP+) — In enzymology, a glycerol 3 phosphate 1 dehydrogenase (NADP+) (EC number|188.8.131.52) is an enzyme that catalyzes the chemical reaction:sn glycerol 3 phosphate + NADP+ ightleftharpoons D glyceraldehyde 3 phosphate + NADPH + H+Thus, the two… … Wikipedia
Glycerol — Glycerine and Glycerin redirect here. For the Bush song, see Glycerine (song). Glycerol … Wikipedia
Glycerol phosphate shuttle — The glycerol 3 phosphate shuttle is a mechanism that regenerates NAD+ from NADH, a by product of glycolysis. Its importance in transporting reducing equivalents is secondary to the malate aspartate shuttle.ReactionIn this shuttle, the enzyme… … Wikipedia
Glycerol 2-dehydrogenase (NADP+) — In enzymology, a glycerol 2 dehydrogenase (NADP+) (EC number|184.108.40.206) is an enzyme that catalyzes the chemical reaction:glycerol + NADP+ ightleftharpoons glycerone + NADPH + H+Thus, the two substrates of this enzyme are glycerol and NADP+,… … Wikipedia