Glycerol-3-phosphate dehydrogenase (NAD(P)+)

Glycerol-3-phosphate dehydrogenase (NAD(P)+)

In enzymology, a glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC number|1.1.1.94) is an enzyme that catalyzes the chemical reaction

:sn-glycerol 3-phosphate + NAD(P)+ ightleftharpoons glycerone phosphate + NAD(P)H + H+

The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD+, and NADP+, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase. Other names in common use include L-glycerol-3-phosphate:NAD(P)+ oxidoreductase, glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide, (phosphate)), glycerol 3-phosphate dehydrogenase (NADP+), and glycerol-3-phosphate dehydrogenase [NAD(P)+] . This enzyme participates in glycerophospholipid metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1TXG.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-30-9."

Gene Ontology (GO) codes


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