2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC number|2.7.7.60) is an enzyme that catalyzes the chemical reaction

:CTP + 2-C-methyl-D-erythritol 4-phosphate $ightleftharpoons$ diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are CTP and 2-C-methyl-D-erythritol 4-phosphate, whereas its two products are diphosphate and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. This enzyme is also called MEP cytidylyltransferase. This enzyme participates in biosynthesis of steroids.

tructural studies

The crystal structure of the "E. coli" 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase PDB link|1I52, PDB link|1INI & PDB link|1INJ, reported by Richard et al (2001), was the first one for an enzyme involved in the MEP pathway.

As of late 2007, 9 other structures have been solved for this class of enzymes, with PDB accession codes PDB link|1H3M, PDB link|1VGT, PDB link|1VGU, PDB link|1VGZ, PDB link|1VPA, PDB link|1W55, PDB link|1W57, PDB link|1W77, and PDB link|2PX7.

References

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External links

Gene Ontology (GO) codes