- Neuraminidase inhibitor
Neuraminidase inhibitors are a class of antiviral drugs targeted at the influenza virus, which work by blocking the function of the viral neuraminidase protein, thus preventing the virus from reproducing by budding from the host cell.
Oseltamivir (Tamiflu) a prodrug, Zanamivir (Relenza), Laninamivir (Inavir), and Peramivir belong to this class. Unlike the M2 inhibitors, which work only against the influenza A, neuraminidase inhibitors act against both influenza A and influenza B.
- This flash animation shows the mode of action of oseltamivir (Tamiflu)
- Replication of influenza virus
- ^ Gubareva LV (2004). "Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors". Virus Research 103 (1–2): 199–203. doi:10.1016/j.virusres.2004.02.034. PMID 15163510. DOI
RNA virus antivirals (primarily J05, also S01AD and D06BB) Hepatitis C Picornavirus Anti-influenza agents Multiple/generalMultiple/unknown Pharmacology: enzyme inhibition Class SubstrateOxidoreductase (EC 1)Transferase (EC 2)Hydrolase (EC 3)Lyase (EC 4)
4.1 Dopa decarboxylase4.2 Carbonic anhydrase
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