Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from their end-pieces.

They are usually very specific for certain amino acids. Examples of endopeptidases include:
* Trypsin - cuts after Arg or Lys, unless followed by Pro. Very strict. Works best at pH 8.
* Chymotrypsin - cuts after Phe, Trp, or Tyr, unless followed by Pro. Cuts more slowly after Asn, His, Met or Leu. Works best at pH 8.
* Elastase - cuts after Ala, Gly, Ser, or Val, unless followed by Pro.
* Thermolysin - cuts "before" Ile, Met, Phe, Trp, Tyr, or Val, unless "preceded" by Pro. Sometimes cuts after Ala, Asp, His or Thr. Heat stable.
* Pepsin - cuts "before" Leu, Phe, Trp or Tyr, unless "preceded" by Pro. Also others, quite nonspecific; works best at pH 2.
* Endopeptidase V8 - cuts after Glu. Works best at pH 8.

External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • endopeptidase — [en΄dōpep′tə dās΄] n. any enzyme, as pepsin, that starts to hydrolyze peptide bonds in the interior of a peptide chain …   English World dictionary

  • endopeptidase — endopeptidazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis peptidinių ryšių hidrolizę tik baltymo arba peptido grandinės viduryje. atitikmenys: angl. endopeptidase; proteinase rus. протеиназа; эндопептидаза ryšiai: sinonimas –… …   Chemijos terminų aiškinamasis žodynas

  • endopeptidase — noun Date: 1936 any of a group of enzymes that hydrolyze peptide bonds within the long chains of protein molecules ; protease compare exopeptidase …   New Collegiate Dictionary

  • Endopeptidase — Endopeptidasen gehören wie die Exopeptidasen zu den Peptidasen. Endopeptidasen spalten enzymatisch Peptidbindungen innerhalb des Proteins. Sie sind meist sehr spezifisch für bestimmte Aminosäuren. Beispiele sind: Pepsin Trypsin: spezifisch für… …   Deutsch Wikipedia

  • Endopeptidase — Peptidase Coupure protéolytique d une chaîne peptidique Les peptidases (ou protéases ou enzymes protéolytiques) sont des enzymes qui brisent les liaisons peptidiques des protéines. On parle alors de coupure protéolytique ou de protéolyse. Ce… …   Wikipédia en Français

  • endopeptidase — An enzyme that cleaves protein at positions within the chain. Formally, the enzymes are peptidyl peptide hydrolases, more usually known as proteinases or proteolytic enzymes …   Dictionary of molecular biology

  • endopeptidase — /en doh pep ti days , dayz /, n. Biochem. an enzyme that catalyzes the cleavage of a polypeptide or protein at interior positions of the amino acid chain. [1935 40; ENDO + PEPTIDASE] * * * …   Universalium

  • endopeptidase — noun Any of a group of enzymes, such as trypsin, chymotrypsin, pepsin and elastase, which catalyze the splitting of polypeptide chains …   Wiktionary

  • endopeptidase — An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini; e.g., pepsin, trypsin. Cf.:exopeptidase. SYN: proteinase. * * * en·do·pep·ti·dase pep tə .dās, .dāz n any of a group of enzymes that… …   Medical dictionary

  • Endopeptidase — Ẹn|do|pep|ti|da|se [↑ endo (1) u. ↑ Peptidase] svw. ↑ Proteinase …   Universal-Lexikon

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”