Endopeptidase

Endopeptidase

Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from their end-pieces.

They are usually very specific for certain amino acids. Examples of endopeptidases include:
* Trypsin - cuts after Arg or Lys, unless followed by Pro. Very strict. Works best at pH 8.
* Chymotrypsin - cuts after Phe, Trp, or Tyr, unless followed by Pro. Cuts more slowly after Asn, His, Met or Leu. Works best at pH 8.
* Elastase - cuts after Ala, Gly, Ser, or Val, unless followed by Pro.
* Thermolysin - cuts "before" Ile, Met, Phe, Trp, Tyr, or Val, unless "preceded" by Pro. Sometimes cuts after Ala, Asp, His or Thr. Heat stable.
* Pepsin - cuts "before" Leu, Phe, Trp or Tyr, unless "preceded" by Pro. Also others, quite nonspecific; works best at pH 2.
* Endopeptidase V8 - cuts after Glu. Works best at pH 8.

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Look at other dictionaries:

  • endopeptidase — [en΄dōpep′tə dās΄] n. any enzyme, as pepsin, that starts to hydrolyze peptide bonds in the interior of a peptide chain …   English World dictionary

  • endopeptidase — endopeptidazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis peptidinių ryšių hidrolizę tik baltymo arba peptido grandinės viduryje. atitikmenys: angl. endopeptidase; proteinase rus. протеиназа; эндопептидаза ryšiai: sinonimas –… …   Chemijos terminų aiškinamasis žodynas

  • endopeptidase — noun Date: 1936 any of a group of enzymes that hydrolyze peptide bonds within the long chains of protein molecules ; protease compare exopeptidase …   New Collegiate Dictionary

  • Endopeptidase — Endopeptidasen gehören wie die Exopeptidasen zu den Peptidasen. Endopeptidasen spalten enzymatisch Peptidbindungen innerhalb des Proteins. Sie sind meist sehr spezifisch für bestimmte Aminosäuren. Beispiele sind: Pepsin Trypsin: spezifisch für… …   Deutsch Wikipedia

  • Endopeptidase — Peptidase Coupure protéolytique d une chaîne peptidique Les peptidases (ou protéases ou enzymes protéolytiques) sont des enzymes qui brisent les liaisons peptidiques des protéines. On parle alors de coupure protéolytique ou de protéolyse. Ce… …   Wikipédia en Français

  • endopeptidase — An enzyme that cleaves protein at positions within the chain. Formally, the enzymes are peptidyl peptide hydrolases, more usually known as proteinases or proteolytic enzymes …   Dictionary of molecular biology

  • endopeptidase — /en doh pep ti days , dayz /, n. Biochem. an enzyme that catalyzes the cleavage of a polypeptide or protein at interior positions of the amino acid chain. [1935 40; ENDO + PEPTIDASE] * * * …   Universalium

  • endopeptidase — noun Any of a group of enzymes, such as trypsin, chymotrypsin, pepsin and elastase, which catalyze the splitting of polypeptide chains …   Wiktionary

  • endopeptidase — An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini; e.g., pepsin, trypsin. Cf.:exopeptidase. SYN: proteinase. * * * en·do·pep·ti·dase pep tə .dās, .dāz n any of a group of enzymes that… …   Medical dictionary

  • Endopeptidase — Ẹn|do|pep|ti|da|se [↑ endo (1) u. ↑ Peptidase] svw. ↑ Proteinase …   Universal-Lexikon

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