- Peramivir
drugbox
IUPAC_name = ("1S,2S,3S,4R")-3- [("1S")-1-Acetamido-2-ethyl-butyl] -4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid
width = 150
CAS_number = 229614-55-5
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PubChem = 151164
DrugBank =
C=15|H=28|N=4|O=4
molecular_weight = 328.407 g/mol
bioavailability =
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routes_of_administration =Peramivir is an experimental
antiviral drug being developed by [http://www.biocryst.com Biocryst Pharmaceuticals] to treatinfluenza . Peramivir is aneuraminidase inhibitor , acting as a transition-state analogue inhibitor of influenzaneuraminidase and thereby preventing new viruses from emerging from infected cells. The development of peramivir is supported by the USDepartment of Health and Human Services as part of the government's effort to prepare for aflu pandemic . [cite press release
title = HHS Pursues Advance Development of New Influenza Antiviral Drug
publisher = USDepartment of Health and Human Services
date =2007-01-04
url = http://www.hhs.gov/news/press/2007pres/20070104.html
accessdate = 2007-05-25]The drug has had a long history. An oral formulation was abandoned by
Johnson and Johnson due to poorbioavailability . [cite news
last = Pollack
first = Andrew
title = Talk of Bird Flu Pandemic Revives Interest in Passed-Over Drugs
publisher =New York Times
date =2005-10-07
url = http://www.nytimes.com/2005/10/07/business/07drug.html?ex=1180411200&en=ccb286fb1a101436&ei=5070
accessdate = 2007-05-25] BioCryst is now developing a injectable version, in partnership with Green Cross Pharmaceuticals inSouth Korea and with Shionogi Pharmaceuticals inJapan . The drug is in Phase II studies. [cite web
title = Evaluation of the Efficacy and Safety of Peramivir in Subjects With Uncomplicated Acute Influenza
publisher =National Institutes of Health
date =2007-03-16
url = http://clinicaltrials.gov/show/NCT00419263
accessdate = 2007-05-25] [cite web
title = Evaluation of the Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-Threatening Influenza
publisher =National Institutes of Health
date =2007-03-28
url = http://clinicaltrials.gov/show/NCT00453999
accessdate = 2007-05-25]ources
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