Matrix metalloproteinase inhibitor

Matrix metalloproteinase inhibitor

A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases (TIMP). There are also cartilage-derived angiogenesis inhibitor‎s.

Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat.


v · d · ePharmacology: enzyme inhibition
Class
Substrate

2.1 COMT · Thymidylate synthase

2.4 PARP

2.5 Dihydropteroate synthetase · Farnesyltransferase

2.6 GABA transaminase

2.7 Nucleotidyltransferase (Integrase, Reverse transcriptase) · Protein kinase (Tyrosine-kinase (Janus kinase))
Hydrolase (EC 3)
Lyase (EC 4)

4.1 Dopa decarboxylase

4.2 Carbonic anhydrase

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Matrix metalloproteinase — Cell surface associated MT1 MMP (MMP14), Green fluorescent protein (GFP) fused to the C term produces a signal on the surface of the cell[1] Matrix metalloproteinases (MMPs) are zinc dependent endopeptidases; other family members are adamalysins …   Wikipedia

  • Matrix metallopeptidase 13 — (collagenase 3) PDB rendering based on 1cxv …   Wikipedia

  • Matrix metallopeptidase 12 — macrophage elastase Identifiers EC number 3.4.24.65 CAS number 146888 86 0 …   Wikipedia

  • Angiogenesis inhibitor — An angiogenesis inhibitor is a substance that inhibits angiogenesis (the growth of new blood vessels). It can be endogenous or come from outside as drug or a dietary component. Every solid tumor (in contrast to liquid tumors like leukemia) needs… …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… …   Wikipedia

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… …   Wikipedia

  • Acetylcholinesterase inhibitor — Acetylcholine …   Wikipedia

  • Dihydropteroate synthase inhibitor — A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides. Tetrahydrofolate synthesis pathway In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”