Cartilage-derived angiogenesis inhibitor
- Cartilage-derived angiogenesis inhibitor
A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I [cite journal |author=Kern BE, Balcom JH, Antoniu BA, Warshaw AL, Fernández-del Castillo C |title=Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer |journal=J. Gastrointest. Surg. |volume=7 |issue=8 |pages=961–8; discussion 969 |year=2003 |pmid=14675705 |doi=] and chondromodulin I [ [http://doi.wiley.com/10.1002/art.20193 Suppression of T Cell Responses by Chondromodulin I, a. Cartilage-Derived Angiogenesis Inhibitory Factor. Therapeutic Potential in Rheumatoid Arthritis ...] ] .
The antiangiogenic effect may be an inhibition of basement membrane degradation.
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