Marimastat

Marimastat

Systematic (IUPAC) name
N-[2,2-dimethyl-1- (methylcarbamoyl)propyl]-2- [hydroxy-(hydroxycarbamoyl)methyl]- 4- methyl-pentanamide
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	oral
Identifiers
CAS number	154039-60-8 Y
ATC code	None
PubChem	CID 119031
DrugBank	APRD00559
ChemSpider	106358 N
UNII	D5EQV23TDS N
ChEMBL	CHEMBL279785 N
Chemical data
Formula	C15H29N3O5
Mol. mass	331.408 g/mol
N(what is this?)  (verify)

Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor.^[1][2]

Marimastat performed poorly in clinical trials,^[3] and development was terminated.^{[citation needed]}

References

1. ^ "Marimastat". National Cancer Institute. http://www.cancer.gov/drugdictionary/?CdrID=42443. 
2. ^ Millar, AW; Brown PD, Moore J, et al. (1998). "Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers". Br J Clin Pharmacol 45: 21–6. PMID 9489589. 
3. ^ Sparano, JA (2004). "Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196". J Clin Oncol 22 (23): 4683–90. PMID 15570070. 

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase inhibitors Antineoplastic and immunomodulating drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Acantuns List of National Basketball Association longest winning streaks Look at other dictionaries: marimastat — An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor …   English dictionary of cancer terms marimastat — noun A novel matrix metalloprotease inhibitor once proposed for cancer treatment …   Wiktionary British Biotech — Infobox Defunct Company company name = British Biotech plc (LSE:BBG Nasdaq:BBIOY) company fate = Merged successor = company merged into Vernalis foundation = 1986 defunct = 2003 location = Oxford, United Kingdom industry = Biotechnology key… …   Wikipedia Matrix metalloproteinase — Cell surface associated MT1 MMP (MMP14), Green fluorescent protein (GFP) fused to the C term produces a signal on the surface of the cell[1] Matrix metalloproteinases (MMPs) are zinc dependent endopeptidases; other family members are adamalysins …   Wikipedia List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia Angiogenesis inhibitor — An angiogenesis inhibitor is a substance that inhibits angiogenesis (the growth of new blood vessels). It can be endogenous or come from outside as drug or a dietary component. Every solid tumor (in contrast to liquid tumors like leukemia) needs… …   Wikipedia Matrix metalloproteinase inhibitor — A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous. The most notorious endogenous metalloproteinases are… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”