DS-1 (drug)

DS-1 (drug)

Systematic (IUPAC) name
4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	372497-52-4
ATC code	?
PubChem	CID 979735
Chemical data
Formula	C18H10Br2ClN3OS
Mol. mass	511.617 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

DS-1 is a drug from the imidazopyridine family which is the first drug developed that acts as a GABA_A receptor agonist selective for the α4β3δ subtype, which is not targeted by other GABA agonists such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.^[1]

See also

• Zolpidem
• Alpidem
• Saripidem

References

1. ^ Wafford, KA; Van Niel, MB; Ma, QP; Horridge, E; Herd, MB; Peden, DR; Belelli, D; Lambert, JJ (2009). "Novel compounds selectively enhance delta subunit containing GABA a receptors and increase tonic currents in thalamus". Neuropharmacology 56 (1): 182–9. doi:10.1016/j.neuropharm.2008.08.004. PMID 18762200. 

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