GABRA4

Gamma-aminobutyric acid (GABA) A receptor, alpha 4, also known as GABRA4, is a human gene.cite web | title = Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2557| accessdate = ]

PBB_Summary
section_title =
summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.cite web | title = Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2557| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McLean PJ, Farb DH, Russek SJ |title=Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster. |journal=Genomics |volume=26 |issue= 3 |pages= 580–6 |year= 1995 |pmid= 7607683 |doi=
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=
*cite journal | author=Yang W, Drewe JA, Lan NC |title=Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site. |journal=Eur. J. Pharmacol. |volume=291 |issue= 3 |pages= 319–25 |year= 1996 |pmid= 8719416 |doi=
*cite journal | author=Kumar R, Lumsden A, Ciclitira PJ, "et al." |title=Human genome search in celiac disease using gliadin cDNA as probe. |journal=J. Mol. Biol. |volume=300 |issue= 5 |pages= 1155–67 |year= 2000 |pmid= 10903861 |doi= 10.1006/jmbi.2000.3927
*cite journal | author=Kumar S, Sieghart W, Morrow AL |title=Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. |journal=J. Neurochem. |volume=82 |issue= 1 |pages= 110–7 |year= 2002 |pmid= 12091471 |doi=
*cite journal | author=Mu W, Cheng Q, Yang J, Burt DR |title=Alternative splicing of the GABA(A) receptor alpha 4 subunit creates a severely truncated mRNA. |journal=Brain Res. Bull. |volume=58 |issue= 5 |pages= 447–54 |year= 2002 |pmid= 12242096 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ma DQ, Whitehead PL, Menold MM, "et al." |title=Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. |journal=Am. J. Hum. Genet. |volume=77 |issue= 3 |pages= 377–88 |year= 2006 |pmid= 16080114 |doi= 10.1086/433195
*cite journal | author=Collins AL, Ma D, Whitehead PL, "et al." |title=Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. |journal=Neurogenetics |volume=7 |issue= 3 |pages= 167–74 |year= 2007 |pmid= 16770606 |doi= 10.1007/s10048-006-0045-1
*cite journal | author=Lagrange AH, Botzolakis EJ, Macdonald RL |title=Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. |journal=J. Physiol. (Lond.) |volume=578 |issue= Pt 3 |pages= 655–76 |year= 2007 |pmid= 17124266 |doi= 10.1113/jphysiol.2006.122135

External links

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