Methylmalonyl-CoA

Methylmalonyl-CoA
Identifiers
CAS number	1264-45-5
PubChem	123909
MeSH	methylmalonyl-coenzyme+A
Properties
Molecular formula	C25H40N7O19P3S
Molar mass	867.608 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methylmalonyl-CoA is the coenzyme A linked form of methylmalonic acid. Methylmalonyl-CoA is formed from propionyl-CoA by propionyl-CoA carboxylase by help of biotin (vitamin B₇). It is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B₁₂ as a cofactor. In this way, it enters the Krebs cycle, and is thus part of one of the anaplerotic reactions. The following diagram demonstrates the aforementioned reactions:

Propionyl CoA → Methylmalonyl CoA → Succinyl CoA ^[1]

See also

• Methylmalonyl CoA epimerase

References

1. ^ Hoffbrand,A.V., Moss, P.A.H, Pettit, J.E. Essential Haematology. Blackwell publishing. 5th Ed. 2006. p. 46 [1]