Ganglionic eminence

Ganglionic eminence
Coronal section in the forebrain of an embryonic mouse at 12.5 days of gestation (preplate stage), showing the lateral and medial ganglionic eminences (LGE, MGE) from which GABAergic interneurons migrate to the cortical anlage (left, yellow). Glutamatergic neurons destined for the cortex are generated locally in the cortical ventricular zone and migrate radially (right, red).

In neuroanatomy and neuroembryology, a ganglionic eminence (GE) is a transitory brain structure present in the embryonic and fetal stages of brain development. The eminences are found in the ventral part of the telencephalon, where they form bulges in the ventricles. These bulges develop into the basal ganglia.[1] They also contribute significantly in building up the GABAergic cortical cell population.


Ganglionic eminences are categorized into three groups based on location:

  • Lateral ganglionic eminences (LGE)
  • Medial ganglionic eminences (MGE)
  • Caudal ganglionic eminences (CGE)

In humans

In humans, ganglionic eminences serve as the source of GABAergic thalamic neurons, which migrate through another transient brain structure peculiar to humans, the gangliothalamic body (GTB). GEs also present an intermediate target for the axons growing from the thalamus into the cortex and vice versa. They disappear just before birth.


  1. ^ Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed.. Sinauer Associates. pp. 555–8. ISBN 978-0-87893-697-7. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Ganglionic eminence — …   Википедия

  • Ганглионарный бугорок — …   Википедия

  • Neural development — comprises the processes that generate, shape, and reshape the nervous system, from the earliest stages of embryogenesis to the final years of life. The study of neural development aims to describe the cellular basis of brain development and to… …   Wikipedia

  • CDE — is a three letter abbreviation that may refer to:Education* California Department of Education * Colorado Department of Education, part of the Law and Government of Colorado * Center for Distance Education at University of Alaska Fairbanks *… …   Wikipedia

  • Reelin — is a protein found mainly in the brain, but also in the spinal cord, blood and other body organs and tissues. Reelin is crucial for regulating the processes of neuronal migration and positioning in the developing brain.Besides this important role …   Wikipedia

  • MGE — is a three letter acronym, which may mean: *Dobbins Air Reserve Base *Madison Gas and Electric *MGE UPS Systems *Mobile genetic elements *Medial Ganglionic Eminence …   Wikipedia

  • Ge — may refer to:word: * Ge, Old English pronoun, written ye in Middle and Modern English * Gē , an ancient Chinese dagger axenames: * Nikolai Ge, a Russian painter * Ge (Cyrillic) (Г, г), a letter of the Cyrillic alphabet * Ge with upturn (Ґ, ґ), a… …   Wikipedia

  • LGE — may refer to:* LG Electronics, a South Korean electronics company * Louisville Gas Electric, a utilities company based in Louisville, Kentucky * Lebor Gabála Érenn, a Middle Irish collection of poems * La Grande Encyclopédie , an encyclopedia… …   Wikipedia

  • Germinal matrix — In anatomy, the germinal matrix is a highly cellular and highly vascularized region in the brain from which cells migrate out during brain development. The germinal matrix is the source of both neurons and glial cells and is most active between 8 …   Wikipedia

  • Germinal matrix hemorrhage — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = radio eMedicineTopic = 305 MeshID = Germinal matrix hemorrhage is a bleeding into the subependymal germinal matrix with or without… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”