Cephalic flexure

Cephalic flexure
Cephalic flexure
Gray651.png
Brain of human embryo of four and a half weeks, showing interior of fore-brain. (Cephalic flexure visible at center top.)
Latin flexura mesencephalica
Gray's subject #184 737
Code TE E5.14.3.3.0.0.3

The mesencephalic flexure or cephalic flexure is the first flexure, or bend, of the embryonic brain; it appears in the region of the mid-brain. In human embryos it generally occurs at the end of the 3rd week/beginning of 4th.

By means of it the fore-brain is bent in a ventral direction around the anterior end of the notochord and fore-gut, with the result that the floor of the fore-brain comes to lie almost parallel with that of the hind-brain.

This flexure causes the mid-brain to become, for a time, the most prominent part of the brain, since its dorsal surface corresponds with the convexity of the curve. As a consequence, the cardiac plate, which was previously anterior to the forebrain, approximates its adult location in what will become the thoracic region.

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This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained within it may be outdated.

v · d · ePrenatal development/Mammalian development of nervous system (GA 9.733 and GA 10.1002, TE E5.13-16)
Neurogenesis
Cranial neural crest (Cardiac neural crest complex) · Truncal neural crest

Rostral neuropore

Neuromere/Rhombomere

Cephalic flexure · Pontine flexure

Alar plate (sensory) · Basal plate (motor)

Glioblast · Neuroblast

Germinal matrix
Eye development
Auditory development
note: NS is mostly ectoderm, but mesoderm is precursor for epineurium, perineurium, and endoneurium

M: CNS

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M: EYE

anat(g/a/p)/phys/devp/prot

noco/cong/tumr, epon

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M: EAR

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