P2RX3

Purinergic receptor P2X, ligand-gated ion channel, 3
Identifiers
Symbols	P2RX3; MGC129956; P2X3
External IDs	OMIM: 600843 MGI: 1097160 HomoloGene: 1922 GeneCards: P2RX3 Gene
Gene Ontology Molecular function • purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • receptor activity • extracellular ATP-gated cation channel activity • extracellular ATP-gated cation channel activity • ion channel activity • ATP binding Cellular component • integral to plasma membrane • membrane • axon • intracellular part Biological process • response to hypoxia • transport • cation transport • signal transduction • neuromuscular synaptic transmission • response to heat • response to cold • response to carbohydrate stimulus • positive regulation of calcium ion transport into cytosol • urinary bladder smooth muscle contraction • peristalsis • response to ATP • purinergic nucleotide receptor signaling pathway • purinergic nucleotide receptor signaling pathway • regulation of synaptic plasticity • behavioral response to pain • positive regulation of calcium-mediated signaling • response to stimulus • sensory perception of taste Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5024	228139
Ensembl	ENSG00000109991	ENSMUSG00000027071
UniProt	P56373	Q3UR32
RefSeq (mRNA)	XM_001126192	NM_145526
RefSeq (protein)	XP_001126192	NP_663501.2
Location (UCSC)	Chr 11: 57.11 – 57.14 Mb	Chr 2: 84.84 – 84.88 Mb
PubMed search	[1]	[2]

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.^[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.^[2]

See also

• Purinergic receptor

References

1. ^ Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902. 
2. ^ ^{a b} "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5024. 

Further reading

• North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951. 
• Jarvis MF (2005). "Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain". Expert Opin. Ther. Targets 7 (4): 513–22. doi:10.1517/14728222.7.4.513. PMID 12885270. 
• Kennedy C, Leff P (1995). "Painful connection for ATP". Nature 377 (6548): 385–6. doi:10.1038/377385a0. PMID 7566110. 
• Lewis C, Neidhart S, Holy C et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons". Nature 377 (6548): 432–5. doi:10.1038/377432a0. PMID 7566120. 
• Garcia-Guzman M, Soto F, Gomez-Hernandez JM et al. (1997). "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue". Mol. Pharmacol. 51 (1): 109–18. PMID 9016352. 
• Cook SP, McCleskey EW (2000). "ATP, pain and a full bladder". Nature 407 (6807): 951–2. doi:10.1038/35039648. PMID 11069162. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Renton T, Yiangou Y, Baecker PA et al. (2003). "Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp". Journal of orofacial pain 17 (3): 245–50. PMID 14520770. 
• Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species". Mol. Pharmacol. 66 (6): 1525–35. doi:10.1124/mol.104.000851. PMID 15331767. 
• Fabbretti E, Sokolova E, Masten L et al. (2005). "Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites". J. Biol. Chem. 279 (51): 53109–15. doi:10.1074/jbc.M409772200. PMID 15475563. 
• Brown DA, Yule DI (2007). "Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation". Biochim. Biophys. Acta 1773 (2): 166–75. doi:10.1016/j.bbamcr.2006.09.020. PMC 1861828. PMID 17052768. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1861828. 

External links

• MeSH P2RX3+protein,+human

Ionotropic glutamates

Ligand-gated only	AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated	NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’	GluD (δ1, δ2)

ATP-gated channels

Purinergic receptors

P2X (1, 2, 3, 4, 5, 6, 7)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)