GRIA2

Glutamate receptor, ionotropic, AMPA 2, also known as GRIA2, is a human gene.cite web | title = Entrez Gene: GRIA2 glutamate receptor, ionotropic, AMPA 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2891| accessdate = ]

PBB_Summary
section_title =
summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene, which includes the generation of flip and flop isoforms that vary in their signal transduction properties.cite web | title = Entrez Gene: GRIA2 glutamate receptor, ionotropic, AMPA 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2891| accessdate = ]

ee also

* AMPA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Soundarapandian MM, Tu WH, Peng PL, "et al." |title=AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke. |journal=Mol. Neurobiol. |volume=32 |issue= 2 |pages= 145–55 |year= 2007 |pmid= 16215279 |doi=
*cite journal | author=Sun W, Ferrer-Montiel AV, Schinder AF, "et al." |title=Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1443–7 |year= 1992 |pmid= 1311100 |doi=
*cite journal | author=McNamara JO, Eubanks JH, McPherson JD, "et al." |title=Chromosomal localization of human glutamate receptor genes. |journal=J. Neurosci. |volume=12 |issue= 7 |pages= 2555–62 |year= 1992 |pmid= 1319477 |doi=
*cite journal | author=Sommer B, Keinänen K, Verdoorn TA, "et al." |title=Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. |journal=Science |volume=249 |issue= 4976 |pages= 1580–5 |year= 1990 |pmid= 1699275 |doi=
*cite journal | author=Sommer B, Köhler M, Sprengel R, Seeburg PH |title=RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. |journal=Cell |volume=67 |issue= 1 |pages= 11–9 |year= 1991 |pmid= 1717158 |doi=
*cite journal | author=Paschen W, Hedreen JC, Ross CA |title=RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. |journal=J. Neurochem. |volume=63 |issue= 5 |pages= 1596–602 |year= 1994 |pmid= 7523595 |doi=
*cite journal | author=Köhler M, Kornau HC, Seeburg PH |title=The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B. |journal=J. Biol. Chem. |volume=269 |issue= 26 |pages= 17367–70 |year= 1994 |pmid= 7545935 |doi=
*cite journal | author=Eastwood SL, Burnet PW, Beckwith J, "et al." |title=AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. |journal=Neuroreport |volume=5 |issue= 11 |pages= 1325–8 |year= 1994 |pmid= 7919190 |doi=
*cite journal | author=Sun W, Ferrer-Montiel AV, Montal M |title=Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain. |journal=Neuroreport |volume=5 |issue= 4 |pages= 441–4 |year= 1994 |pmid= 8003671 |doi=
*cite journal | author=Higuchi M, Single FN, Köhler M, "et al." |title=RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. |journal=Cell |volume=75 |issue= 7 |pages= 1361–70 |year= 1994 |pmid= 8269514 |doi=
*cite journal | author=McLaughlin DP, Cheetham ME, Kerwin RW |title=Expression of alternatively-spliced glutamate receptors in human hippocampus. |journal=Eur. J. Pharmacol. |volume=244 |issue= 1 |pages= 89–92 |year= 1993 |pmid= 8420792 |doi=
*cite journal | author=Srivastava S, Osten P, Vilim FS, "et al." |title=Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. |journal=Neuron |volume=21 |issue= 3 |pages= 581–91 |year= 1998 |pmid= 9768844 |doi=
*cite journal | author=Matsuda S, Mikawa S, Hirai H |title=Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1765–8 |year= 1999 |pmid= 10501226 |doi=
*cite journal | author=Hirai H, Matsuda S |title=Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells. |journal=Neurosci. Res. |volume=34 |issue= 4 |pages= 281–7 |year= 2000 |pmid= 10576550 |doi=
*cite journal | author=Aruscavage PJ, Bass BL |title=A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. |journal=RNA |volume=6 |issue= 2 |pages= 257–69 |year= 2000 |pmid= 10688364 |doi=
*cite journal | author=Osten P, Khatri L, Perez JL, "et al." |title=Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. |journal=Neuron |volume=27 |issue= 2 |pages= 313–25 |year= 2000 |pmid= 10985351 |doi=
*cite journal | author=Chung HJ, Xia J, Scannevin RH, "et al." |title=Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. |journal=J. Neurosci. |volume=20 |issue= 19 |pages= 7258–67 |year= 2001 |pmid= 11007883 |doi=
*cite journal | author=Armstrong N, Gouaux E |title=Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. |journal=Neuron |volume=28 |issue= 1 |pages= 165–81 |year= 2000 |pmid= 11086992 |doi=
*cite journal | author=Krampfl K, Schlesinger F, Zörner A, "et al." |title=Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing. |journal=Eur. J. Neurosci. |volume=15 |issue= 1 |pages= 51–62 |year= 2002 |pmid= 11860506 |doi=
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200

External links

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