OXCT1

OXCT1
3-oxoacid CoA transferase 1

PDB rendering based on 1m3e.
Identifiers
Symbols OXCT1; OXCT; SCOT
External IDs OMIM601424 MGI1914291 HomoloGene377 GeneCards: OXCT1 Gene
EC number 2.8.3.5
RNA expression pattern
PBB GE OXCT1 202780 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5019 67041
Ensembl ENSG00000083720 ENSMUSG00000022186
UniProt P55809 A1E285
RefSeq (mRNA) NM_000436 NM_024188.6
RefSeq (protein) NP_000427 NP_077150.1
Location (UCSC) Chr 5:
41.73 – 41.87 Mb
Chr 15:
3.98 – 4.11 Mb
PubMed search [1] [2]

Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial is an enzyme that in humans is encoded by the OXCT1 gene.[1][2]

This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.[2]

See also

  • Succinyl-CoA:3-oxoacid CoA transferase deficiency

References

Further reading


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