GRIA4

GRIA4

Glutamate receptor, ionotrophic, AMPA 4, also known as GRIA4, is a human gene.cite web | title = Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2893| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2893| accessdate = ]

ee also

* AMPA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McNamara JO, Eubanks JH, McPherson JD, "et al." |title=Chromosomal localization of human glutamate receptor genes. |journal=J. Neurosci. |volume=12 |issue= 7 |pages= 2555–62 |year= 1992 |pmid= 1319477 |doi=
*cite journal | author=Hardy M, Younkin D, Tang CM, "et al." |title=Expression of non-NMDA glutamate receptor channel genes by clonal human neurons. |journal=J. Neurochem. |volume=63 |issue= 2 |pages= 482–9 |year= 1994 |pmid= 7518497 |doi=
*cite journal | author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11679–82 |year= 1994 |pmid= 8163463 |doi=
*cite journal | author=Fletcher EJ, Nutt SL, Hoo KH, "et al." |title=Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. |journal=Recept. Channels |volume=3 |issue= 1 |pages= 21–31 |year= 1996 |pmid= 8589990 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9466455 |doi=
*cite journal | author=Carvalho AL, Kameyama K, Huganir RL |title=Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors. |journal=J. Neurosci. |volume=19 |issue= 12 |pages= 4748–54 |year= 1999 |pmid= 10366608 |doi=
*cite journal | author=Chen L, Chetkovich DM, Petralia RS, "et al." |title=Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. |journal=Nature |volume=408 |issue= 6815 |pages= 936–43 |year= 2001 |pmid= 11140673 |doi= 10.1038/35050030
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200
*cite journal | author=Tomiyama M, Rodríguez-Puertas R, Cortés R, "et al." |title=Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. |journal=Synapse |volume=45 |issue= 4 |pages= 245–9 |year= 2002 |pmid= 12125045 |doi= 10.1002/syn.10098
*cite journal | author=Pasternack A, Coleman SK, Jouppila A, "et al." |title=Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49662–7 |year= 2003 |pmid= 12393905 |doi= 10.1074/jbc.M208349200
*cite journal | author=Correia SS, Duarte CB, Faro CJ, "et al." |title=Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6307–13 |year= 2003 |pmid= 12471040 |doi= 10.1074/jbc.M205587200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Makino C, Fujii Y, Kikuta R, "et al." |title=Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=116 |issue= 1 |pages= 17–22 |year= 2003 |pmid= 12497607 |doi= 10.1002/ajmg.b.10041
*cite journal | author=Coleman SK, Cai C, Mottershead DG, "et al." |title=Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein. |journal=J. Neurosci. |volume=23 |issue= 3 |pages= 798–806 |year= 2003 |pmid= 12574408 |doi=
*cite journal | author=Pasternack A, Coleman SK, Féthière J, "et al." |title=Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. |journal=J. Neurochem. |volume=84 |issue= 5 |pages= 1184–92 |year= 2003 |pmid= 12603841 |doi=
*cite journal | author=Kawahara Y, Ito K, Sun H, "et al." |title=GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain. |journal=Brain Res. Mol. Brain Res. |volume=127 |issue= 1-2 |pages= 150–5 |year= 2004 |pmid= 15306133 |doi= 10.1016/j.molbrainres.2004.05.020
*cite journal | author=Li G, Sheng Z, Huang Z, Niu L |title=Kinetic mechanism of channel opening of the GluRDflip AMPA receptor. |journal=Biochemistry |volume=44 |issue= 15 |pages= 5835–41 |year= 2005 |pmid= 15823042 |doi= 10.1021/bi047413n
*cite journal | author=Nuriya M, Oh S, Huganir RL |title=Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. |journal=J. Neurochem. |volume=95 |issue= 2 |pages= 544–52 |year= 2005 |pmid= 16190873 |doi= 10.1111/j.1471-4159.2005.03410.x
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

External links

*

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